2-deuterio-4-fluorophenol | 1160503-53-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-deuterio-4-fluorophenol
• CAS: 1160503-53-6
• 化学式: C₆H₅FO
• 分子量: 113.096
• InChiKey: RHMPLDJJXGPMEX-WFVSFCRTSA-N

反应信息

• 作为反应物：
  描述：

  三氟甲磺酸酐 、 2-deuterio-4-fluorophenol 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 2-deuterio-4-fluorophenyl trifluoromethanesulfonate
  参考文献：
  名称：

  Palladium-Catalyzed Direct Synthesis of Carbazoles via One-Pot N-Arylation and Oxidative Biaryl Coupling: Synthesis and Mechanistic Study

  摘要：

  An efficient catalytic system has been developed for the synthesis of carbazoles by one-pot N-arylation and oxidative biaryl coupling. A significant substituent effect of the diarylamine intermediate on oxidative Coupling was observed. Mechanistic studies of oxidative coupling, including trapping of reaction intermediates and kinetic isotope effect experiments, are also presented.

  DOI：

  10.1021/jo9003376
• 作为产物：
  描述：

  在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 1.0h， 以479 mg的产率得到2-deuterio-4-fluorophenol
  参考文献：
  名称：

  Palladium-Catalyzed Direct Synthesis of Carbazoles via One-Pot N-Arylation and Oxidative Biaryl Coupling: Synthesis and Mechanistic Study

  摘要：

  An efficient catalytic system has been developed for the synthesis of carbazoles by one-pot N-arylation and oxidative biaryl coupling. A significant substituent effect of the diarylamine intermediate on oxidative Coupling was observed. Mechanistic studies of oxidative coupling, including trapping of reaction intermediates and kinetic isotope effect experiments, are also presented.

  DOI：

  10.1021/jo9003376