N-(24-azido-5β-cholane-7α,12α-diol 7,12-diacetate)-N'-(3'β-azido-5'β-cholane-7'α,12'α-diol 7',12'-diacetate)-3α,24'-oxamide | 1101182-41-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: N-(24-azido-5β-cholane-7α,12α-diol 7,12-diacetate)-N'-(3'β-azido-5'β-cholane-7'α,12'α-diol 7',12'-diacetate)-3α,24'-oxamide
• CAS: 1101182-41-5
• 化学式: C₅₈H₉₀N₈O₁₀
• 分子量: 1059.4
• InChiKey: KVLSGVXZWCMVHE-LHTHHUNLSA-N

反应信息

• 作为反应物：
  描述：

  N-(24-azido-5β-cholane-7α,12α-diol 7,12-diacetate)-N'-(3'β-azido-5'β-cholane-7'α,12'α-diol 7',12'-diacetate)-3α,24'-oxamide 在 三苯基膦 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 0.25h， 以81%的产率得到N-(24-amino-5β-cholane-7α,12α-diol 7,12-diacetate)-N'-(3'β-amino-5'β-cholane-7'α,12'α-diol 7',12'-diacetate)-3α,24'-oxamide
  参考文献：
  名称：

  Dimeric Cholaphanes with Oxamide Spacers

  摘要：

  Two new dimeric cholaphanes with oxamide spacers were prepared. The spacers bind two identical steroidal subunits through positions 3,3' and 24,24' (head-to-head dimer) or positions 3,24' and 3',24 (head-to-tail dimer).

  DOI：

  10.1007/s00706-007-0768-1
• 作为产物：
  描述：

  N-(24-iodo-5β-cholane-7α,12α-diol 7,12-diacetate)-N'-(3'β-iodo-5'β-cholane-7'α,12'α-diol 7',12'-diacetate)-3α,24'-oxamide 在 sodium azide 、 溶剂黄146 作用下， 以 N-甲基吡咯烷酮 为溶剂， 以93%的产率得到N-(24-azido-5β-cholane-7α,12α-diol 7,12-diacetate)-N'-(3'β-azido-5'β-cholane-7'α,12'α-diol 7',12'-diacetate)-3α,24'-oxamide
  参考文献：
  名称：

  Dimeric Cholaphanes with Oxamide Spacers

  摘要：

  Two new dimeric cholaphanes with oxamide spacers were prepared. The spacers bind two identical steroidal subunits through positions 3,3' and 24,24' (head-to-head dimer) or positions 3,24' and 3',24 (head-to-tail dimer).

  DOI：

  10.1007/s00706-007-0768-1