1-(4-((p-tolylamino)methyl)phenyl)ethanone | 1352347-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-((p-tolylamino)methyl)phenyl)ethanone
• CAS: 1352347-41-1
• 化学式: C₁₆H₁₇NO
• 分子量: 239.317
• InChiKey: WGUQDSQALQKIJF-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  1-[4-[(4-Methylphenyl)iminomethyl]phenyl]ethanone 在 [CpFe(IMes)(CO2)]I 、 水 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 30.5h， 生成 1-(4-((p-tolylamino)methyl)phenyl)ethanone
  参考文献：
  名称：

  NHC-carbene cyclopentadienyl iron based catalyst for a general and efficient hydrosilylation of imines

  摘要：

  已经开发出一种通用且高效的由明确的NHC-卡宾环戊二烯基铁络合物催化的亚胺的水硅化反应。醛亚胺和酮亚胺在温和条件下以及可见光激活下转化为相应的胺。

  DOI：

  10.1039/c1cc14403k

文献信息

• Amine Synthesis through Mild Catalytic Hydrosilylation of Imines using Polymethylhydroxysiloxane and [RuCl2(arene)]2 Catalysts
  作者：Bin Li、Jean-Baptiste Sortais、Christophe Darcel、Pierre H. Dixneuf

  DOI：10.1002/cssc.201100585

  日期：2012.2.13

  Tolerate silicone! The stable [RuCl2(p‐cymene]2 complex is an efficient catalyst for the direct chemoselective hydrosilylation of functionalized aldimines and ketimines into amines, using polymethylhydroxysiloxane as an inexpensive, stable, and safe hydrosilane source. The catalysis operates in ethanol, under air at room temperature, and tolerates the ketone ester and alkene functionality.

  耐硅胶！稳定的[RuCl 2（p- cymene）2络合物是一种有效的催化剂，可使用聚甲基羟基硅氧烷作为廉价，稳定且安全的氢化硅烷源，将官能化的亚胺和酮亚胺直接化学选择性氢化硅烷化为胺。在室温下，并能耐受酮酯和烯烃的官能团。
• A Highly Efficient Base-Metal Catalyst: Chemoselective Reduction of Imines to Amines Using An Abnormal-NHC–Fe(0) Complex
  作者：Mrinal Bhunia、Pradip Kumar Hota、Gonela Vijaykumar、Debashis Adhikari、Swadhin K. Mandal

  DOI：10.1021/acs.organomet.6b00478

  日期：2016.9.12

  A base-metal, Fe(0)-catalyzed hydrosilylation of imines to obtain amines is reported here which outperforms its noble-metal congeners with the highest TON of 17000. The catalyst, (aNHC)Fe(CO)(4), works under very mild conditions, with extremely low catalyst loading (down to 0.005 mol %), and exhibits excellent chemoselectivity. The facile nature of the imine reduction under mild conditions has been further demonstrated by reducing imines towards expensive commercial amines and biologically important N-alkylated sugars, which are difficult to achieve otherwise. A mechanistic pathway and the source of chemoselectivity for imine hydrosilylation have been proposed on the basis of the well-defined catalyst and isolable intermediates along the catalytic cycle.