LX6Rqk5701 | 2016046-95-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: LX6Rqk5701
• 英文别名: [2-[4-(4-aminophenyl)butanoyloxy]-3-pentadecylphenyl] 4-(4-aminophenyl)butanoate
• CAS: 2016046-95-8
• 化学式: C₄₁H₅₈N₂O₄
• 分子量: 642.9
• InChiKey: VLRZIRYGLUVGGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.4
• 重原子数：
  47
• 可旋转键数：
  26
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.51
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-十五烷基邻苯二酚 、 4-(4-氨基苯基)丁酸 在 4-(4-氨基苯基)丁酸 作用下， 生成 LX6Rqk5701
  参考文献：
  名称：

  Compositions for prevention/prophylactic treatment of poison ivy dermatitis

  摘要：

  本发明在一个或多个实施例中，包括3-n-十五烷基邻苯二酚（毒葛油酚饱和同系物）和/或3-n-十七烷基邻苯二酚（毒橡胶油酚饱和同系物）的衍生物，作为预防和/或预防性治疗因接触毒葛和毒橡胶引起的接触性皮炎的组合物。本发明还涉及制造这些化合物的过程。本发明揭示了有效的化合物，用于耐受和减轻主体对漆树科和银杏科植物中含有的过敏原的过敏反应，包括通式（IA）的漆酚酯化合物，通过给予含有至少一种漆酚酯化合物的配方，实现对哺乳动物，包括人类，耐受和减轻漆树科和银杏科植物中含有的过敏原的过敏反应。

  公开号：

  US10322103B2

文献信息

• [EN] COMPOSITIONS FOR PREVENTION/PROPHYLACTIC TREATMENT OF POISON IVY DERMATITIS<br/>[FR] COMPOSITIONS POUR LA PRÉVENTION/LE TRAITEMENT PROPHYLACTIQUE DE LA DERMATITE PROVOQUÉE PAR LE SUMAC VÉNÉNEUX
  申请人：THE UNIV OF MISSISSIPPI

  公开号：WO2016160090A1

  公开（公告）日：2016-10-06

  The present invention, in one or more embodiments, comprises derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3 -n-heptadecyl catechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising urushiol esters of general formula (IA) [Formula should be entered here] tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a formulation containing at least one urushiol ester compound.

  本发明在一个或多个实施例中，包括3-正十五烷基儿茶酚（毒葛酚醛酸酯饱和同分异构体）和/或3-正十七烷基儿茶酚（毒橡胶酚醛酸酯饱和同分异构体）的衍生物，作为预防和/或预防性治疗由毒葛和毒橡胶引起的接触性皮炎的组合物。本发明还涉及制备这种化合物的过程。本发明揭示了能够对抗漆树科和银杏科植物中含有的过敏原，包括通式（IA）[应在此处输入公式]的漆醇酯化合物，能够对哺乳动物，包括人类，进行耐受和脱敏，达到的方法是给予含有至少一种漆醇酯化合物的配方。
• COMPOSITIONS FOR PREVENTION/PROPHYLACTIC TREATMENT OF POISON IVY DERMATITIS
  申请人：The University Of Mississippi

  公开号：EP3274322A1

  公开（公告）日：2018-01-31
• Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis
  申请人：The University of Mississippi

  公开号：US20150202176A1

  公开（公告）日：2015-07-23

  The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.
• US8486998B2
  申请人：——

  公开号：US8486998B2

  公开（公告）日：2013-07-16
• US9029417B2
  申请人：——

  公开号：US9029417B2

  公开（公告）日：2015-05-12