FmocNH(CH2CH2O)5CH2COOSu | 1133459-12-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: FmocNH(CH2CH2O)5CH2COOSu
• 英文别名: FmocNH-PEG5-CH2COONHS；(2,5-dioxopyrrolidin-1-yl) 2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetate
• CAS: 1133459-12-7
• 化学式: C₃₁H₃₈N₂O₁₁
• 分子量: 614.65
• InChiKey: SZNXPJUMCPWDTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  44
• 可旋转键数：
  22
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  148
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  、 FmocNH(CH2CH2O)5CH2COOSu 以 N,N-二甲基甲酰胺 为溶剂， 以50%的产率得到
  参考文献：
  名称：

  Monosialoside with multimer-like anti-influenza potency

  摘要：

  Synthetic glycopeptides capable of assembling in aqueous solution demonstrated enhanced influenza virus blocking potency.

  DOI：

  10.1016/j.mencom.2009.03.002

文献信息

• PEPTIDE-LIPID CONSTRUCTS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
  申请人：Kode Biotech Limited

  公开号：US20130280746A1

  公开（公告）日：2013-10-24

  Peptide-lipid constructs of the structure L-S-F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glyccrolipid (including glyccrophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of agglutination of the cells.
• US8394594B2
  申请人：——

  公开号：US8394594B2

  公开（公告）日：2013-03-12
• [EN] PEPTIDE-LIPID CONSTRUCTS AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS<br/>[FR] CONSTRUCTIONS PEPTIDIQUES-LIPIDIQUES ET LEUR UTILISATION POUR DES APPLICATIONS DIAGNOSTIQUES ET THÉRAPEUTIQUES
  申请人：WEINBERG CRISTINA-SIMONA

  公开号：WO2009035347A1

  公开（公告）日：2009-03-19

  Peptide-lipid constructs of the structure L-S-F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glycerolipid (including glycerophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of agglutination of the cells.