申请人:BIOGEN MA INC.
公开号:US20150361029A1
公开(公告)日:2015-12-17
Compounds of formula (I) can modulate the activity of one or more S 1P receptors. Sphingosine 1-phosphate (S IP) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family, namely S1P1, S1P2, S1P3, S1P4, and S1P5 (formerly EDG1, EDG5, EDG3, EDG6 and EDG8). The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation propagate second messenger signals via activation of heterotrimeric G-protein alpha (Ga.) subunits and beta-gamma (G( )y) dimers.
化合物的公式(I)可以调节一个或多个S1P受体的活性。鞘氨醇1-磷酸(S1P)是一种溶血磷脂介质,通过刺激内皮细胞分化基因(EDG)受体家族的五个成员,即S1P1、S1P2、S1P3、S1P4和S1P5(曾用名EDG1、EDG5、EDG3、EDG6和EDG8),引发多种细胞反应。EDG受体是G蛋白偶联受体(GPCR),在刺激下通过激活异三聚体G蛋白α(Ga.)亚基和β-γ(G()y)二聚体传递第二信使信号。