6,7-dimethoxy-1-(1-naphthyl)-3,4-dihydronaphthalene-2-carbaldehyde | 883221-04-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6,7-dimethoxy-1-(1-naphthyl)-3,4-dihydronaphthalene-2-carbaldehyde
• 英文别名: 6,7-dimethoxy-1-naphthalen-1-yl-3,4-dihydronaphthalene-2-carbaldehyde
• CAS: 883221-04-3
• 化学式: C₂₃H₂₀O₃
• 分子量: 344.41
• InChiKey: YPEBTBXLPFQJMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6,7-dimethoxy-1-(1-naphthyl)-3,4-dihydronaphthalene-2-carbaldehyde 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 以100%的产率得到[6,7-dimethoxy-1-(1-naphthyl)-3,4-dihydronaphthalen-2-yl]methanol
  参考文献：
  名称：

  Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones

  摘要：

  alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.01.013
• 作为产物：
  描述：

  6,7-二甲氧基-3,4-二氢-2H-1-萘酮 在 四(三苯基膦)钯 三溴化磷 、 sodium carbonate 作用下， 以 乙二醇二甲醚 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 78.0h， 生成 6,7-dimethoxy-1-(1-naphthyl)-3,4-dihydronaphthalene-2-carbaldehyde
  参考文献：
  名称：

  Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones

  摘要：

  alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.01.013

文献信息

• Methodology for the synthesis of 1,2-disubstituted arylnaphthalenes from α-tetralones
  作者：Simon S. Moleele、Joseph P. Michael、Charles B. de Koning

  DOI：10.1016/j.tet.2006.01.013

  日期：2006.3

  alpha-Tetralones were initially converted into 1-bromo-dihydronaphthalene-2-carbaldehydes and 1-bromo-naphthalene-2carbaldehydes. These precursors were then subjected to Suzuki coupling reactions to afford 1,2-disubstituted aryldihydronaphthalenes and 1,2-disubstituted arylnaphthalenes, respectively. The former products were oxidized with DDQ to give 1,2-disubstituted arylnaphthalenes. (c) 2006 Elsevier Ltd. All rights reserved.