1H-benzo[c][1,2]diazepine-3-carboxylic acid | 72119-92-7

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 1H-benzo[c][1,2]diazepine-3-carboxylic acid
• 英文别名: 1h-1,2-Benzodiazepine-3-carboxylic；1H-1,2-benzodiazepine-3-carboxylic acid
• CAS: 72119-92-7
• 化学式: C₁₀H₈N₂O₂
• 分子量: 188.186
• InChiKey: MZHUTGQZAZLFKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1H-benzo[c][1,2]diazepine-3-carboxylic acid 以18%的产率得到
  参考文献：
  名称：

  GARANTI L.; ZECCHI G., J. HETEROCYCL. CHEM., 1979, 16, NO 5, 1061-1062

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl 1H-1,2-benzodiazepine-3-carboxylate 、 sodium hydroxide 、 乙醇 以89%的产率得到
  参考文献：
  名称：

  GARANTI L.; ZECCHI G., J. HETEROCYCL. CHEM., 1979, 16, NO 5, 1061-1062

  摘要：

  DOI：

文献信息

• Novel tricyclic diazepines tocolytic oxytocin receptor antagonists
  申请人：Wyeth

  公开号：US20030008863A1

  公开（公告）日：2003-01-09

  This invention provides novel tricyclic diazepine compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including treatment of preterm labor, dysmenorrhea, endometritis, and for suppressing labor prior to caesarean delivery. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

  这项发明提供了新颖的三环二氮杂平烯类化合物，以及利用这些化合物进行治疗和/或预防和/或抑制可能通过催产素拮抗剂活性得到缓解或减轻的疾病的方法和药物组合物，包括早产、经痛、子宫内膜炎的治疗，以及在剖宫产前抑制分娩。这些化合物还可用于提高农场动物的生育率、生存率和同步发情；并且可能在预防和治疗中枢神经系统中催产素系统功能障碍，包括强迫症（OCD）和神经精神障碍方面有用。
• Novel hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
  申请人：Wyeth

  公开号：US20020183311A1

  公开（公告）日：2002-12-05

  The present invention provides substituted 10,11-Dihydro-5H-benzo[e]-pyrrolo[1,2-a][1,4]diazepine and 9,10-Dihydro-4H-3a,5,9-triaza-benzo[f]azulene compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression labor at term prior to caesarean deliver, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals.

  本发明提供了取代的10,11-二氢-5H-苯并[e]吡咯[1,2-a][1,4]二氮杂环庚烷和9,10-二氢-4H-3a,5,9-三氮杂-苯并[f]吖啉类化合物，以及利用这些化合物进行治疗和/或预防和/或抑制可能通过催产素拮抗剂活性得到缓解或减轻的疾病的方法和药物组合物，包括预防和/或抑制早产、在剖宫产前抑制足月分娩、以及治疗痛经。这些化合物还可用于提高生育率、提高农场动物的存活率和同步发情。
• Novel cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
  申请人：Wyeth

  公开号：US20030004159A1

  公开（公告）日：2003-01-02

  The present invention provides tricyclic carboxamide compounds and methods and pharmaceutical compositions for their use in treatment, prevention, or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression of labor at term prior to caesarean deliver, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

  本发明提供了三环羧酰胺化合物以及其在治疗、预防或抑制可能通过催产素拮抗剂活性得到缓解或减轻的疾病中的应用的方法和制药组合物，包括预防和/或抑制早产、术前剖腹产前期的分娩抑制以及治疗痛经。这些化合物还可用于提高农场动物的生育率、提高存活率和同步动物的发情；并且可能对中枢神经系统中催产素系统功能障碍，包括强迫症（OCD）和神经精神障碍的预防和治疗具有用处。
• [EN] AROMATIC HETEROCYCLIC FUSED INDOLOBENZADIAZEPINE HCV NS5B INHIBITORS<br/>[FR] INHIBITEURS DE NS5B DU VHC DE TYPE INDOLOBENZADIAZÉPINE CONDENSÉE À UN HÉTÉROCYCLE AROMATIQUE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2009120650A1

  公开（公告）日：2009-10-01

  The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

  该披露提供了式（I）的化合物，包括它们的盐，以及使用这些化合物的组合物和方法。这些化合物对丙型肝炎病毒（HCV）具有活性，并可用于治疗感染了HCV的人。
• Novel cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
  申请人：Wyeth

  公开号：US20030027815A1

  公开（公告）日：2003-02-06

  The present invention provides novel tricyclic benzodiazepine carboxamides compounds and methods and pharmaceutical compositions utilizing them for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression suppression of preterm labor, suppression of labor at term prior to caesarean delivery, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatmraent of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.

  本发明提供了新型三环苯二氮䓬啶羧酰胺化合物，以及利用它们进行治疗和/或预防和/或抑制可能通过催产素拮抗剂活性得到缓解或减轻的疾病的方法和药物组合物，包括预防和/或抑制早产、术前剖宫产前期的分娩抑制，以及治疗痛经。这些化合物还可用于提高农场动物的生育率、提高存活率和同步动物的发情期；并且可能有助于预防和治疗中枢神经系统中催产素系统功能障碍，包括强迫症（OCD）和神经精神障碍。