thiasporine A

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: thiasporine A
• 英文别名: Thiasporine A；2-(2-aminophenyl)-5-methoxy-1,3-thiazin-4-one
• 化学式: C₁₁H₁₀N₂O₂S
• 分子量: 234.279
• InChiKey: NXOGKVZRJVBGOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  90
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  thiasporine A 、 三甲基硅烷化重氮甲烷 以 甲醇 为溶剂， 反应 2.0h， 以47%的产率得到thiasporine A
  参考文献：
  名称：

  Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived Actinomycetospora chlora

  摘要：

  Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 mu M.

  DOI：

  10.1021/np500929z

文献信息

• Thiasporines A–C, Thiazine and Thiazole Derivatives from a Marine-Derived <i>Actinomycetospora chlora</i>
  作者：Peng Fu、John B. MacMillan

  DOI：10.1021/np500929z

  日期：2015.3.27

  Thiasporine A (1), the first natural product with a 5-hydroxy-4H-1,3-thiazin-4-one moiety, along with two new thiazole derivatives, thiasporines B and C (2 and 3), were isolated from the marine-derived Actinomycetospora chlora SNC-032. The structures of 1-3 were established on the basis of comprehensive spectroscopic analysis and chemical methods. Thiasporine A showed cytotoxicity against the non-small-cell lung cancer cell line H2122 with an IC50 value of 5.4 mu M.