1,4-Bis(3-azidopropyl)benzene | 1298049-00-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-Bis(3-azidopropyl)benzene
• CAS: 1298049-00-9
• 化学式: C₁₂H₁₆N₆
• 分子量: 244.299
• InChiKey: TZULIMRCXSCTCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  28.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butylmethyl ((S)-1-oxo-1-((3S,6S,10aS)-5-oxo-3-((R)-1-phenylprop-2-ynylcarbamoyl)decahydropyrrolo[1,2-a]azocin-6-ylamino)propan-2-yl)carbamate 、 1,4-Bis(3-azidopropyl)benzene 在 copper(II) sulfate 、 sodium ascorbate 作用下， 以 水 、 叔丁醇 为溶剂， 生成
  参考文献：
  名称：

  Potent Bivalent Smac Mimetics: Effect of the Linker on Binding to Inhibitor of Apoptosis Proteins (IAPs) and Anticancer Activity

  摘要：

  We have synthesized and evaluated a series of nonpeptidic, bivalent Smac mimetics as antagonists of the inhibitor of apoptosis proteins and new anticancer agents. All these bivalent Smac mimetics bind to full-length XIAP with low nanomolar affinities and function as ultrapotent antagonists of XIAP. While these Smac mimetics bind to cIAP1/2 with similar low nanomolar affinities, their potencies to induce degradation of cIAP1/2 proteins in cells differ by more than 100-fold. The most potent bivalent Smac mimetics inhibit cell growth with IC(50) from 1 to 3 nM in the MDA-MB-231 breast cancer cell line and are 100 times more potent than the least potent compounds. Determination of intracellular concentrations for several representative compounds showed that the linkers in these bivalent Smac mimetics significantly affect their intracellular concentrations and hence the overall cellular activity. Compound 27 completely inhibits tumor growth in the MDA-MB-231 xenografts while causing no signs of toxicity in the animals.

  DOI：

  10.1021/jm101651b

文献信息

• Quantum-dot display substrate, method for preparing the same, and display panel
  申请人：BOE TECHNOLOGY GROUP CO., LTD.

  公开号：US10608196B2

  公开（公告）日：2020-03-31

  The present disclosure discloses a quantum-dot display substrate, a method for preparing the same, and a display panel. The quantum-dot display substrate includes a substrate and a plurality of light emitting sub-pixels disposed on the substrate, in which each of the light emitting sub-pixels includes a quantum-dot light emitting layer, and the quantum-dot light emitting layer includes a crosslinked network formed by crosslinking quantum dots having a crosslinkable ligand with a crosslinking agent.

  本公开涉及一种量子点显示基板、其制备方法以及显示面板。量子点显示基板包括基板和设置在基板上的多个发光子像素，其中每个发光子像素包括量子点发光层，量子点发光层包括交联网络，该交联网络由具有可交联配体的量子点与交联剂交联形成。
• QUANTUM-DOT DISPLAY SUBSTRATE, METHOD FOR PREPARING THE SAME, AND DISPLAY PANEL
  申请人：Boe Technology Group Co., Ltd.

  公开号：US20190207136A1

  公开（公告）日：2019-07-04

  The present disclosure discloses a quantum-dot display substrate, a method for preparing the same, and a display panel. The quantum-dot display substrate includes a substrate and a plurality of light emitting sub-pixels disposed on the substrate, in which each of the light emitting sub-pixels includes a quantum-dot light emitting layer, and the quantum-dot light emitting layer includes a crosslinked network formed by crosslinking quantum dots having a crosslinkable ligand with a crosslinking agent.