tert-butyl 1-(5-(3-acetyl-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-4-ylamino)pyridin-2-yl)pyrroloidin-3-yl(methyl)carbamate | 1448362-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tert-butyl 1-(5-(3-acetyl-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-4-ylamino)pyridin-2-yl)pyrroloidin-3-yl(methyl)carbamate
• 英文别名: Tert-butyl 1-{5-[3-acetyl-6-(3,5-dichloro-4-hydroxy-phenyl)-1,5-naphthyridin-4-ylamino]pyridin-2-yl}pyrrolidin-3-yl(methyl)carbamate；tert-butyl N-[1-[5-[[3-acetyl-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-4-yl]amino]pyridin-2-yl]pyrrolidin-3-yl]-N-methylcarbamate
• CAS: 1448362-10-4
• 化学式: C₃₁H₃₂Cl₂N₆O₄
• 分子量: 623.539
• InChiKey: QFZUKQDKHNFXCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  tert-butyl 1-(5-(3-acetyl-6-(3,5-dichloro-4-hydroxyphenyl)-1,5-naphthyridin-4-ylamino)pyridin-2-yl)pyrroloidin-3-yl(methyl)carbamate 、 三氟乙酸 、 以to afford the desired product (57 mg, 49% over two steps) as an orange-yellow solid的产率得到1-(6-(3,5-Dichloro-4-hydroxyphenyl)-4-{6-[3-(methylamino)pyrrolidin-1-y]pyridin-3-ylamino}-1,5-naphthyridin-3-yl)ethanone trihydrochloride
  参考文献：
  名称：

  1,5-naphthyridine derivatives and MELK inhibitors containing the same

  摘要：

  本发明涉及一种由式(I)所表示的化合物。

  公开号：

  US09345709B2

文献信息

• 1,5-NAPHTHYRIDINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME
  申请人：Onco Therapy Science, Inc.

  公开号：US20150005302A1

  公开（公告）日：2015-01-01

  The present invention directs a compound represented by formula (I).

  本发明涉及一种由式(I)所表示的化合物。
• SHEET SET FOR SOLAR CELL SEALING
  申请人：Mitsui Chemicals Tohcello, Inc.

  公开号：EP2822043A1

  公开（公告）日：2015-01-07

  The invention is a sheet set for encapsulating a solar battery including a first encapsulating sheet and a second encapsulating sheet which are disposed between a light-incident surface protective member and a back surface protective member, and are used to encapsulate solar battery elements. When the first encapsulating sheet and the second encapsulating sheet are subjected to a heating and pressurization treatment in which the first encapsulating sheet and the second encapsulating sheet are heated and depressurized at 150°C and 250 Pa for three minutes, and then are heated and pressurized at 150°C and 100 kPa for 15 minutes, a volume resistivity of the first encapsulating sheet, which is based on JIS K6911 and is measured at a temperature of 100°C with an applied voltage of 500 V, is higher than a volume resistivity of the second encapsulating sheet. The first encapsulating sheet is disposed between the light-incident surface protective member and the solar battery elements. The second encapsulating sheet has at least one polar group selected from a carboxyl group, an ester group, a hydroxyl group, an amino group, and an acetal group.

  本发明是一种用于封装太阳能电池的片材组，包括第一封装片材和第二封装片材，它们被放置在入射光表面保护部件和背面保护部件之间，用于封装太阳能电池元件。 在对第一封装片和第二封装片进行加热和加压处理时，先将第一封装片和第二封装片在 150°C 和 250 Pa 的温度下加热和减压 3 分钟，然后在 150°C 和 100 kPa 的温度下加热和加压 15 分钟，第一封装片的体积电阻率（基于 JIS K6911 并在 100°C 温度和 500 V 的外加电压下测量）高于第二封装片的体积电阻率。 第一封装片位于光入射表面保护部件和太阳能电池元件之间。 第二封装片具有至少一个选自羧基、酯基、羟基、氨基和缩醛基的极性基团。
• ENCAPSULATING MATERIAL FOR SOLAR CELL AND SOLAR CELL MODULE
  申请人：MITSUI CHEMICALS TOHCELLO, INC.

  公开号：US20150000739A1

  公开（公告）日：2015-01-01

  An encapsulating material for solar cell is made of a resin composition containing a crosslinkable resin, and satisfies the following 1) and 2). 1) When the encapsulating material for solar cell is immersed in acetone at 23° C. for one hour after a crosslinking treatment in which the encapsulating material for solar cell is heated and depressurized at 150° C. and 250 Pa for three minutes, and then is heated and pressurized at 150° C. and 100 kPa for 15 minutes, an acetone-absorbing ratio is in a range of 3.5 weight % to 12.0 weight % with respect to the weight of the above-described crosslinking-treated encapsulating material for solar cell. 2) A volume resistivity of the above-described crosslinking-treated encapsulating material for solar cell, which is based on JIS K6911 and measured at a temperature of 100° C. with an applied voltage of 500 V, is in a range of 1.0×10 13 Ω·cm to 1.0×10 18 Ω·cm.
• US9067937B2
  申请人：——

  公开号：US9067937B2

  公开（公告）日：2015-06-30
• US9193854B2
  申请人：——

  公开号：US9193854B2

  公开（公告）日：2015-11-24