1-(5-fluorobenzo[b]thiophen-2-yl)ethylamine | 159009-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 1-(5-fluorobenzo[b]thiophen-2-yl)ethylamine
• 英文别名: 1-(5-fluoro-1-benzothiophen-2-yl)ethanamine
• CAS: 159009-09-3
• 化学式: C₁₀H₁₀FNS
• 分子量: 195.261
• InChiKey: VWZRQXBKTGFEMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  54.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(5-fluorobenzo[b]thiophen-2-yl)ethylamine 、 N-(异丙氧羰基)-L-缬氨酸 、 氯甲酸异丁酯 在 N-甲基哌啶 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 N1-[1-(5-fluorobenzo[b]thiophen-2-yl)ethyl]-N2-isopropoxycarbonyl-L-valinamide
  参考文献：
  名称：

  Condensed heterocyclic derivatives and agricultural or horticultural

  摘要：

  本发明提供了一种由以下公式表示的缩合杂环衍生物：##STR1## 其中，R1表示低烷基，烯基或类似基团，R2、R3、R4、R5和R6独立地表示氢原子，低烷基或类似基团，W表示--OC（O）--、--SC（O）--或类似基团，Z表示2-吲哚基团或类似基团。本发明还提供了一种农业或园艺杀菌剂，其包括已知作为杀菌剂有效的缩合衍生物的量。根据本发明的农业或园艺杀菌剂，在不损害非真菌光合植物的情况下，表现出对霜霉病和晚疫病的优越控制效果。

  公开号：

  US05348976A1

文献信息

• Condensed heterocyclic derivatives and agricultural or horticultural fungicides containing the same
  申请人：KUMIAI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0587110A2

  公开（公告）日：1994-03-16

  The present invention provides a condensed heterocyclic derivative represented by a formula:    wherein R¹ represents a lower alkyl group, an alkenyl group, or the like, R², R³, R⁴, R⁵, and R⁶ independently represent a hydrogen atom, a lower alkyl, or the like, W is represented by -OC(O)-, -SC(O)-, or the like, and Z represents a 2-indolyl group or the like. The present invention also provides an agricultural or horticultural fungicide which comprises an amount of the condensed derivative known to be effective as a fungicide. The agricultural or horticultural fungicide according to the present invention exhibits a superior control effect for downy mildew and late blight, without harm to nonfungal, photosynthesizing plants.

  本发明提供了一种由式表示的缩合杂环衍生物： 其中R¹代表低级烷基、烯基或类似基团，R²、R³、R⁴、R⁵和R⁶独立地代表氢原子、低级烷基或类似基团，W由-OC(O)-、-SC(O)-或类似基团代表，Z代表2-吲哚基或类似基团。本发明还提供了一种农用或园艺用杀真菌剂，它包含一定量的已知有效杀真菌的缩合衍生物。根据本发明的农业或园艺杀真菌剂对霜霉病和晚疫病有很好的防治效果，对非真菌的光合作用植物无害。
• VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL INHIBITOR
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：EP3404021A1

  公开（公告）日：2018-11-21

  A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker: wherein A represents a fused ring which may have a substituent, the fused ring being composed of a 5-membered heteroaryl group or a 5-membered or 6-membered heterocyclic ring and a benzene ring or the like, the 5-membered heteroaryl group having one to three identical or different heteroatoms as a ring-constituting element(s) having at least one substituent such as an alkoxy group having 1 to 8 carbon atoms and substituted with 1 to 5 halogen atoms; R represents a hydrogen atom or the like; B represents CR5(Q1) or NQ2, herein Q1 represents a benzimidazole group which may have a substituent; Q2 represents an alkyl group having 1 to 8 carbon atoms which may have a substituent, a heteroaryl group which may have a substituent, or the like; R0, R1, R2, R3, R4, and R5 each represent a hydrogen atom or the like; and n and m each represent 0, 1, or 2, provide that n and m are not 0 and 2 at the same time.

  由以下通式（I）代表的化合物、该化合物的同系物或立体异构体、其药学上可接受的盐或其溶液可用作电压依赖性 T 型钙通道阻滞剂： 其中 A 代表可具有取代基的融合环，该融合环由 5 元杂芳基或 5 元或 6 元杂环和苯环或类似物组成，5 元杂芳基具有 1 至 3 个相同或不同的杂原子作为成环元素，具有至少一个取代基，例如具有 1 至 8 个碳原子并被 1 至 5 个卤素原子取代的烷氧基；R 代表氢原子或类似物；B 代表 CR5(Q1) 或 NQ2，其中 Q1 代表可能具有取代基的苯并咪唑基；Q2 代表可能具有取代基的具有 1 至 8 个碳原子的烷基、可能具有取代基的杂芳基或类似物；R0、R1、R2、R3、R4 和 R5 各代表氢原子或类似物；n 和 m 各代表 0、1 或 2，但 n 和 m 不能同时为 0 和 2。
• VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL BLOCKER
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：US20190077767A1

  公开（公告）日：2019-03-14

  A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker: wherein A represents a fused ring which may have a substituent, the fused ring being composed of a 5-membered heteroaryl group or a 5-membered or 6-membered heterocyclic ring and a benzene ring or the like, the 5-membered heteroaryl group having one to three identical or different heteroatoms as a ring-constituting element(s) having at least one substituent such as an alkoxy group having 1 to 8 carbon atoms and substituted with 1 to 5 halogen atoms; R represents a hydrogen atom or the like; B represents CR5(Q1) or NQ2, herein Q1 represents a benzimidazole group which may have a substituent; Q2 represents an alkyl group having 1 to 8 carbon atoms which may have a substituent, a heteroaryl group which may have a substituent, or the like; R0, R1, R2, R3, R4, and R5 each represent a hydrogen atom or the like; and n and m each represent 0, 1, or 2, provide that n and m are not 0 and 2 at the same time.
• US5348976A
  申请人：——

  公开号：US5348976A

  公开（公告）日：1994-09-20