bisdimethylphenyl ether | 31313-29-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bisdimethylphenyl ether
• 英文别名: bis-(2,3-dimethyl-phenyl) ether；Xylyl ether；1-(2,3-dimethylphenoxy)-2,3-dimethylbenzene
• CAS: 31313-29-8
• 化学式: C₁₆H₁₈O
• 分子量: 226.318
• InChiKey: GKQBSTJUOVBUDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  bisdimethylphenyl ether 在 三氯化铝 、 三氯化砷 作用下， 生成 10-Chlor-3,4,6,7-tetramethyl-phenoxarsin
  参考文献：
  名称：

  Saint-Ruf,G. et al., Recueil des Travaux Chimiques des Pays-Bas, 1974, vol. 93, p. 251 - 252

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR THE PREPARATION OF ESTETROL<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION D'ESTÉTROL
  申请人：CRYSTAL PHARMA SAU

  公开号：WO2015040051A1

  公开（公告）日：2015-03-26

  The invention relates to a process for obtaining Estetrol or a salt or solvate thereof, the process comprising: a) reacting a compound of formula (IV) or a salt or solvate thereof, wherein R1 is a hydroxyl protecting group selected from a silyl ether, an ether, an ester, a carbamate and a carbonate, and R2 is a hydroxyl protecting group selected from an ether, with an oxidizing agent selected from OsO4 or a source of osmium tetroxide to produce Estetrol or a compound of formula (II) or a salt or solvate thereof wherein R1 is as defined previously; and b) if a compound of formula (II) is obtained in step a), deprotecting said compound to produce Estetrol.

  该发明涉及一种获取Estetrol或其盐或溶剂化合物的方法，该方法包括：a) 反应化合物式（IV）或其盐或溶剂化合物，其中R1是从硅醚、醚、酯、氨甲酸酯和碳酸酯中选择的羟基保护基，R2是从醚中选择的羟基保护基，与从OsO4或四氧化锇的来源中选择的氧化剂反应，以产生Estetrol或化合物式（II）或其盐或溶剂化合物，其中R1如前所定义；b) 如果在步骤a)中获得化合物式（II），则去保护所述化合物以产生Estetrol。
• PROCESS FOR PRODUCING AROMATIC POLYCARBOXYLIC ACID
  申请人：Shibamoto Akihiro

  公开号：US20110071314A1

  公开（公告）日：2011-03-24

  A process for producing an aromatic polycarboxylic acid in which all alkyl groups are converted into carboxyl groups in a high yield by decreasing a residual amount of an intermediate product is provided. The process comprises oxygen-oxidizing an aromatic compound having a plurality of alkyl groups (e.g., durene) in the presence of a catalyst containing a cyclic imino unit having an N—OR group (wherein R represents a hydrogen atom or a protecting group for a hydroxyl group) and a transition metal co-catalyst (e.g., a cobalt compound, a manganese compound, and a zirconium compound) under heating in a lower-temperature zone and a higher-temperature zone to produce an aromatic polycarboxylic acid in which a plurality of alkyl groups are oxidized into carboxyl groups. In an initial stage of the reaction, the reaction may be conducted in a first lower-temperature zone (a reaction temperature of 60 to 120° C. and a second lower-temperature zone (an intermediate temperature zone) (a reaction temperature of 100 to 140° C.); and then, in a latter stage of the reaction, the reaction may be conducted in a higher-temperature zone (a reaction temperature of 110 to 150° C.).

  提供一种生产芳香族多羧酸的方法，其中所有烷基转化为羧基，产率高，通过减少中间产物的残留量实现。该方法包括在低温区和高温区加热的条件下，在催化剂的存在下，将具有多个烷基的芳香化合物（例如二甲苯）进行氧气氧化，其中催化剂包含具有N-OR基团（其中R代表氢原子或羟基的保护基团）和过渡金属共催化剂（例如钴化合物、锰化合物和锆化合物）的环状亚胺单元，以产生芳香族多羧酸，其中多个烷基被氧化为羧基。在反应的初始阶段，反应可以在第一低温区（反应温度为60至120°C）和第二低温区（中间温度区）（反应温度为100至140°C）进行；然后，在反应的后期阶段，反应可以在较高温度区（反应温度为110至150°C）进行。
• [EN] EFFLUX PUMP INHIBITORS<br/>[FR] INHIBITEURS DE POMPE D'ECOULEMENT
  申请人：MICROCIDE PHARMACEUTICALS, INC.

  公开号：WO1999037667A1

  公开（公告）日：1999-07-29

  (EN) Compounds are described which have efflux pump inhibitor activity. Also described are methods of using such efflux pump inhibitor compounds and pharmaceutical compositions which include such compounds.(FR) L'invention concerne des composés présentant une activité d'inhibiteur de pompe d'écoulement. L'invention concerne également des méthodes d'utilisation de ces composés inhibiteurs et des compositions pharmaceutiques renfermant de tels composés.

  （中文翻译）描述了具有外排泵抑制剂活性的化合物。还描述了使用这种外排泵抑制剂化合物的方法和包括这种化合物的药物组合物。
• Electrical insulating oil and oil-filled electrical appliances
  申请人：NIPPON PETROCHEMICALS COMPANY, LIMITED

  公开号：EP0114385A2

  公开（公告）日：1984-08-01

  An improved electrical insulating oil and oil-filled electrical appliances impregnated therewith. The electrical insulating oil is quite suitable for use in oil-filled electrical appliances in which insulating materials or dielectric materials made of plastics are employed. The electrical insulating oil comprises (a) an electrical insulating oil except polyaromatic hydrocarbons and (b) an aromatic monoolefin and/or diolefin having two condensed or noncondensed aromatic nuclei.

  一种改进的电气绝缘油和浸渍了这种油的充油电器。这种电气绝缘油非常适用于使用塑料绝缘材料或介电材料的充油电器。电绝缘油包括：(a) 不含多芳烃的电绝缘油；(b) 具有两个缩合或非缩合芳香族核的芳香族单烯烃和/或二烯烃。
• Process for preparation of aromatic polycarboxylic acids and intermediates therefor
  申请人：THE UPJOHN COMPANY

  公开号：EP0125342A1

  公开（公告）日：1984-11-21

  A method is described for autoxidizing particular ortho-dialkyl substituted aromatic compounds using a particular type of solvent which gives rise to the formation of 3-alkanoyloxyphthalide compounds, some of which are novel. The phthalides in turn are ionically oxidized to their corresponding aromatic polycarboxylic acids. Combination of the two methods provides a means for converting ortho dialkyl substituted aromatic compounds directly to the corresponding polycarboxylic acids in higher yields and at generally lower overall temperatures and reaction conditions compared to prior art methods. Polycarboxylic acids so obtained are known to be useful in the preparation of alkyds, polyesters, and the like, and, particularly, in the formation of the corresponding acid anhydrides which are used in the preparation of organic high temperature polymers such as polyamides, polyamideimides, and polyimides.

  描述了一种使用特定类型溶剂对特定邻二烷基取代的芳香族化合物进行自氧化的方法，该方法可生成 3-烷酰氧基邻苯二甲酸盐化合物，其中一些是新型化合物。 这些邻苯二甲酸盐又被离子氧化成相应的芳香族多羧酸。 与现有技术相比，这两种方法的结合提供了一种将正交二烷基取代的芳香族化合物直接转化为相应的聚羧酸的方法，收率更高，总体温度和反应条件通常更低。 众所周知，这样得到的聚羧酸可用于制备醇酸树脂、聚酯等，特别是形成相应的酸酐，用于制备有机高温聚合物，如聚酰胺、聚酰胺酰亚胺和聚酰亚胺。