3-[6-benzyloxy-2,2,5,7-tetramethylchroman-8-yl]propanal | 137418-81-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 3-[6-benzyloxy-2,2,5,7-tetramethylchroman-8-yl]propanal
• 英文别名: 3-(2,2,5,7-Tetramethyl-6-phenylmethoxy-3,4-dihydrochromen-8-yl)propanal
• CAS: 137418-81-6
• 化学式: C₂₃H₂₈O₃
• 分子量: 352.474
• InChiKey: MWVUGPCVSGSBFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙酰乙酸乙酯 、 3-[6-benzyloxy-2,2,5,7-tetramethylchroman-8-yl]propanal 生成 ethyl 7-[6-benzyloxy-2,2,5,7-tetramethylchroman-8-yl]-5-hydroxy-3-oxoheptanoate
  参考文献：
  名称：

  Synthesis of a New type of Antioxidant possessing Inhibitory Activity against HMG-CoA Reductase

  摘要：

  The 6-hydroxychromans (4) and (6), and 5-hydroxy-2,3-dihydrobenzo[b]furans (5) and (7) bearing a 4-hydroxypyran-2-one moiety were synthesized. All the compounds exhibited potent activity against lipid peroxidation. The chroman (4) possessed inhibitory activity against HMG-CoA reductase in addition to the antioxidant character.

  DOI：

  10.3987/com-94-6908
• 作为产物：
  描述：

  3-(6-Benzyloxy-2,2,5,7-tetramethyl-chroman-8-yl)-propan-1-ol 在 pyridine-SO3 complex 、 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 生成 3-[6-benzyloxy-2,2,5,7-tetramethylchroman-8-yl]propanal
  参考文献：
  名称：

  Synthesis of a New type of Antioxidant possessing Inhibitory Activity against HMG-CoA Reductase

  摘要：

  The 6-hydroxychromans (4) and (6), and 5-hydroxy-2,3-dihydrobenzo[b]furans (5) and (7) bearing a 4-hydroxypyran-2-one moiety were synthesized. All the compounds exhibited potent activity against lipid peroxidation. The chroman (4) possessed inhibitory activity against HMG-CoA reductase in addition to the antioxidant character.

  DOI：

  10.3987/com-94-6908

文献信息

• 4-Hydroxytetrahydropyran-2-one derivatives
  申请人：Fujirebio Inc.

  公开号：US05149834A1

  公开（公告）日：1992-09-22

  4-hydroxytetrahydropyran-2-one derivatives with general formula (I) are useful as cholesterol reducing agents as well as lipid reducing agents, serving as inhibitors of HMG-CoA reductase, and capable of inhibiting the biosynthesis of peroxidized lipids, and therefore effective for curing arteriosclerosis: ##STR1## wherein R.sub.1 represent hydrogen or a 2-tetrahydropyranyl group; R.sub.2 and R.sub.3 each represent hydrogen or an alkyl group having 1 to 6 carbon atoms; R.sub.4 represents hydrogen, an alkyl group having 1 to 6 carbon atoms, an alkenyl group having 2 to 6 carbon atoms, an aryl group, an aralkyl group, an acyl group, an aroyl group or a substituted sulfonyl group; A represents --CH.sub.2 CH.sub.2 --, or --CH.dbd.CH--; and n is an integer of 1 or 2, and intermediates for synthesizing the 4-hydroxytetrahydropyran-2-one derivatives are disclosed.

  具有一般式(I)的4-羟基四氢吡喃-2-酮衍生物可用作降低胆固醇和脂质的药剂，作为HMG-CoA还原酶的抑制剂，能够抑制过氧化脂质的生物合成，因此对治疗动脉硬化有效：其中R.sub.1代表氢或2-四氢吡喃基团；R.sub.2和R.sub.3各代表氢或具有1至6个碳原子的烷基基团；R.sub.4代表氢，具有1至6个碳原子的烷基基团，具有2至6个碳原子的烯基基团，芳基，芳基烷基，酰基，芳基酰基或取代磺酰基；A代表--CH.sub.2 CH.sub.2--或--CH.dbd.CH--; n为1或2的整数，公开了用于合成4-羟基四氢吡喃-2-酮衍生物的中间体。
• 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents
  申请人：FUJIREBIO INC.

  公开号：EP0445827B1

  公开（公告）日：1996-09-25
• US5149834A
  申请人：——

  公开号：US5149834A

  公开（公告）日：1992-09-22