2-Methyl-2--1,3-oxido-propan | 3840-38-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Methyl-2--1,3-oxido-propan
• 英文别名: 3-Methyl-3-<2>naphthyloxymethyl-oxetan；3-methyl-3-naphthalen-2-yloxymethyl-oxetane；3-methyl-3-(2-naphthyloxymethyl)oxetane；3-Methyl-3-(naphthalen-2-yloxymethyl)oxetane
• CAS: 3840-38-8
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: LLWGYSQUVLETNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Methyl-2--1,3-oxido-propan 在 硫酸 作用下， 生成 2-甲基-2-(萘-2-基氧基甲基)丙烷-1,3-二醇
  参考文献：
  名称：

  Cheymol,J. et al., Bulletin de la Societe Chimique de France, 1965, p. 694 - 700

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴萘 、 3-甲基-3-羟甲基氧杂环丁烷 在 copper(l) iodide 、 N-([1,1'-biphenyl]-2-yl)-N′-(2-phenylnaphthalen-1-yl)benzene-1,2-diamine 、 sodium t-butanolate 作用下， 以 二甲基亚砜 为溶剂， 生成 2-Methyl-2--1,3-oxido-propan
  参考文献：
  名称：

  Room‐Temperature Copper‐Catalyzed Etherification of Aryl Bromides

  摘要：

  We disclose the development of a Cu‐catalyzed C−O coupling method utilizing a new N1,N2‐diarylbenzene‐1,2‐diamine ligand, L8. Under optimized reaction conditions, structurally diverse aryl and heteroaryl bromides underwent efficient coupling with a variety of alcohols at room temperature using an L8‐based catalyst. Notably, the L8‐derived catalyst exhibited enhanced activity when compared to the L4‐based system previously disclosed for C−N coupling, namely the ability to functionalize aryl bromides containing acidic functional groups. Mechanistic studies demonstrate that C−O coupling utilizing L8 ⋅ Cu involves rate‐limiting alkoxide transmetallation, resulting in a mechanism of C−O bond formation that is distinct from previously described Pd‐, Cu‐, or Ni‐based systems. This lower energy pathway leads to rapid C−O bond formation; a 7‐fold increase relative to what is seen with other ligands. The results presented in this report overcome limitations in previously described C−O coupling methods and introduce a new ligand that we anticipate may be useful in other Cu‐catalyzed C‐heteroatom bond‐forming reactions.

  DOI：

  10.1002/anie.202400333

文献信息

• Naphthalene derivative, binaphthalene derivative and biphenyl derivative and cationically curable compound
  申请人：TOAGOSEI CO., LTD.

  公开号：EP1069120A1

  公开（公告）日：2001-01-17

  A naphthalene derivative, binaphthalene derivative and biphenyl derivative, all having an oxetane group, capable of being cationically polymerized and a cationically curable compound containing a naphthalene derivative having an oxetanyl group and an aromatic compound having an epoxy group or an oxetanyl group.

  一种萘衍生物、联萘衍生物和联苯衍生物，它们都具有一个氧杂环丁烷基团，能够被阳离子聚合，以及一种阳离子可固化的化合物，其中包含一个具有氧杂环丁烷基团的萘衍生物和一个具有环氧基团或氧杂环丁烷基团的芳香族化合物。
• US6365760B1
  申请人：——

  公开号：US6365760B1

  公开（公告）日：2002-04-02
• US6469108B2
  申请人：——

  公开号：US6469108B2

  公开（公告）日：2002-10-22