Atrolactic acid hemihydrate | 75378-83-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Atrolactic acid hemihydrate
• 英文别名: 2-hydroxy-2-phenylpropanoic acid;hydrate
• CAS: 75378-83-5
• 化学式: C18H22O7
• 分子量: 350.4
• InChiKey: BCZRQUYXNLVFOZ-UHFFFAOYSA-N

物化性质

• 熔点：
  87-91 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  1.13
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  116
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Atrolactic acid hemihydrate 、 2-氯乙醇 生成 2-chloroethyl 2-hydroxy-2-phenylpropionate
  参考文献：
  名称：

  Esters of unsymmetrically 2-substituted glycolic acid dimers

  摘要：

  这项发明涉及非对称2-取代乙醇酸二聚体的酯类，其制备过程以及它们在制备非对称3,6-取代的1,4-二氧杂环戊烷-2,5-二酮中的应用。

  公开号：

  US05254718A1

文献信息

• Use of hydroxycarboxylic acids to enhance therapeutic effects of topical compositions for fungal infections and pigmented spots.
  申请人：Van Scott, Eugene J., Dr.

  公开号：EP0273202A2

  公开（公告）日：1988-07-06

  Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof. Topical application of the cosmetic or therapeutic compostion has been found to achieve a substantial increase in cosmetic or therapeutic effect of the active ingredient in humans and domesticated animals.

  本发明公开了增强外用药剂治疗效果的组合物和方法。该化妆品或治疗组合物可包括一种或多种化妆品或药物制剂，其总量为组合物总重量的 0.01% 至 40%，以及一种或多种羟基羧酸或相关化合物，其总量为组合物总重量的 0.01% 至 99%。化妆品和药物制剂可包括但不限于老年斑、皱纹和角化去除剂；维生素；芦荟；防晒霜；美黑、脱色和洗发剂；抗酵母菌；抗真菌、抗细菌和抗病毒剂；局部支气管扩张剂和局部心血管制剂；激素制剂；血管扩张剂；维甲酸和其他皮肤病制剂。羟基羧酸及相关化合物包括有机 alpha 和 beta 羟基羧酸、alpha 和 beta 酮羧酸及其盐类。研究发现，局部施用美容或治疗复合剂可大幅提高活性成分对人类和驯养动物的美容或治疗效果。
• Additives enhancing topical actions of therapeutic agents
  申请人：Van Scott, Eugene J., Dr.

  公开号：EP0599819A2

  公开（公告）日：1994-06-01

  Composition and method for enhancing therapeutic effects of topically applied agents are disclosed. The cosmetic or therapeutic composition may include one or more of cosmetic or pharmaceutical agents present in a total amount of from 0.01 to 40 percent and one or more of hydroxycarboxylic acids or related compounds present in a total amount of from 0.01 to 99 percent by weight of the total composition. The cosmetic and pharmaceutical agents may include but not limited to age spots, wrinkles and keratoses removing agents; vitamins; aloes; sun screens; tanning, depigmenting and shampooing agents; antiyeasts; antifungal, antibacterial and antiviral agents; topical bronchial dilators and topical cardiovascular agents; hormonal agents; vasodilators; retinoids and other dermatological agents. The hydroxycarboxylic acids and related compounds include organic alpha and beta hydroxycarboxylic acids, alpha and beta ketocarboxylic acids and salts thereof. Topical application of the cosmetic or therapeutic composition has been found to achieve a substantial increase in cosmetic or therapeutic effect of the active ingredient in humans and domesticated animals.

  本发明公开了增强外用药剂治疗效果的组合物和方法。该化妆品或治疗组合物可包括一种或多种化妆品或药物制剂，其总量为组合物总重量的 0.01% 至 40%，以及一种或多种羟基羧酸或相关化合物，其总量为组合物总重量的 0.01% 至 99%。化妆品和药物制剂可包括但不限于老年斑、皱纹和角化去除剂；维生素；芦荟；防晒霜；美黑、脱色和洗发剂；抗酵母菌；抗真菌、抗细菌和抗病毒剂；局部支气管扩张剂和局部心血管制剂；激素制剂；血管扩张剂；维甲酸和其他皮肤病制剂。羟基羧酸及相关化合物包括有机 alpha 和 beta 羟基羧酸、alpha 和 beta 酮羧酸及其盐类。研究发现，局部使用化妆品或治疗组合物可大大提高活性成分对人类和驯养动物的美容或治疗效果。
• High-throughput methods and systems for screening of compounds to treat/prevent kidney disorders
  申请人：Levinson Douglas

  公开号：US20050233461A1

  公开（公告）日：2005-10-20

  The invention concerns arrays, systems and methods for screening compounds, compositions or conditions useful to treat or prevent kidney diseases. These methods are useful to discover, optimize and select compounds, compositions, or conditions that prevent, inhibit, induce, modify, or reverse physical-state transitions, particularly in-vivo physical-state transitions relating to disease causing processes such as development and growth of renal calculi. Such compounds, compositions, or conditions can be exploited to treat, prevent or manage the disease itself, the cause of the disease, or the symptoms of the disease.

  本发明涉及用于筛选治疗或预防肾脏疾病的化合物、组合物或条件的阵列、系统和方法。这些方法有助于发现、优化和选择能够预防、抑制、诱导、改变或逆转物理状态转变，特别是与致病过程（如肾结石的发育和生长）有关的体内物理状态转变的化合物、组合物或条件。此类化合物、组合物或条件可用于治疗、预防或控制疾病本身、病因或疾病症状。
• US5254718A
  申请人：——

  公开号：US5254718A

  公开（公告）日：1993-10-19
• US5371001A
  申请人：——

  公开号：US5371001A

  公开（公告）日：1994-12-06