o-(2-Aminoethyl)benzylamin | 90565-21-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-(2-Aminoethyl)benzylamin
• 英文别名: 1-aminomethyl-2-(2-aminoethyl)-benzene；2-aminomethyl-phenethylamine；Homo-o-xylylendiamin；1¹.2²-Diamino-1-methyl-2-aethyl-benzol；2-Aminomethyl-phenaethylamin；2-[2-(Aminomethyl)phenyl]ethan-1-amine；2-[2-(aminomethyl)phenyl]ethanamine
• CAS: 90565-21-2
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: JUTSLNNVUDLPLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  o-(2-Aminoethyl)benzylamin 、 copper(II) perchlorate 以 not given 为溶剂， 生成
  参考文献：
  名称：

  Expanded Ring Metal Complexes of o-Xylylenediamine and Homo-o-xylylenediamine

  摘要：

  DOI：

  10.1021/ic50014a009

文献信息

• Small-molecule modulators of TRP-P8 activity
  申请人：Moreno Ofir

  公开号：US20070232603A1

  公开（公告）日：2007-10-04

  Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

  提供了小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及含有小分子Trp-p8激动剂的组合物，以及用于识别和表征新型小分子Trp-p8调节剂的方法，以及降低Trp-p8表达细胞的存活能力和/或抑制生长的方法，激活Trp-p8介导的阳离子流入的方法，刺激凋亡和/或坏死的方法，以及用于治疗疾病的相关方法，包括肺癌、乳腺癌、结肠癌和/或前列腺癌等癌症，以及与Trp-p8表达相关的其他疾病，如良性前列腺增生。
• SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY
  申请人：Moreno Ofir

  公开号：US20080255185A1

  公开（公告）日：2008-10-16

  Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

  提供了小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及含有小分子Trp-p8激动剂的组合物，以及识别和表征新型小分子Trp-p8调节剂的方法，以及降低Trp-p8表达细胞的生存能力和/或抑制生长的方法，激活Trp-p8介导的阳离子内流的方法，刺激细胞凋亡和/或坏死的方法，以及相关治疗疾病的方法，包括肺癌、乳腺癌、结肠癌和/或前列腺癌等癌症，以及与Trp-p8表达相关的其他疾病，如良性前列腺增生等。
• Small-Molecule modulators of TRP-P8 activity
  申请人：DENDREON CORPORATION

  公开号：EP2510925A2

  公开（公告）日：2012-10-17

  Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

  本发明提供了小分子 Trp-p8 调节剂，包括 Trp-p8 激动剂和 Trp-p8 拮抗剂，以及包含小分子 Trp-p8 激动剂的组合物、鉴定和表征新型小分子 Trp-p8 调节剂的方法和降低 Trp-p8 表达细胞活力和/或抑制其生长的方法、激活 Trp-p8 介导的阳离子流入的方法、刺激细胞凋亡和/或坏死的方法，以及治疗疾病的相关方法，包括肺癌、乳腺癌、结肠癌和/或前列腺癌等癌症，以及与 Trp-p8 表达相关的良性前列腺增生等其他疾病。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Cu: MVol.B4, 25, page 1503 - 1504
  作者：

  DOI：——

  日期：——
• US3940441A
  申请人：——

  公开号：US3940441A

  公开（公告）日：1976-02-24