5-methyl-2-furyl-2-thienylmethanol | 70406-83-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 5-methyl-2-furyl-2-thienylmethanol
• 英文别名: 5-Methyl-2-furyl-(2-thienyl)-carbinol；(5-methyl-furan-2-yl)-thiophen-2-yl-methanol；(5-Methylfuran-2-yl)(thiophen-2-yl)methanol；(5-methylfuran-2-yl)-thiophen-2-ylmethanol
• CAS: 70406-83-6
• 化学式: C₁₀H₁₀O₂S
• 分子量: 194.254
• InChiKey: PXPMIRYGLVOPSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-methyl-2-furyl-2-thienylmethanol 以 水 为溶剂， 反应 36.0h， 以95%的产率得到2-(2-thienyl)-3-methyl-4-hydroxycyclopent-2-en-1-one
  参考文献：
  名称：

  A New Simple Procedure for the Isomerization of 2-Furylcarbinols to Cyclopentenones

  摘要：

  The previously reported acid catalyzed isomerization of 2-furylcarbinols to 5-alkyl-4-hydroxycyclopent-2-enones was performed in boiling water in the absence of any acid catalyst. In this case the reaction led to the formation of more stable isomer 2-alkyl- or 2-aryl-4-hydroxycyclopent-2-enones. The reaction of chiral 2-furylcarbinol in the presence of zinc chloride gave a racemic cyclopentenone while 2-furylcarbinol did not undergo racemization. A new mechanism for the conversion of 2-furylcarbinols into cyclopentenone is proposed.

  DOI：

  10.3987/com-99-s5

文献信息

• Copper-Catalyzed Ring Opening of Furans as a Concise Route to Polysubstituted Furans under Mild Conditions
  作者：Biaolin Yin、Huiyue Yu、Zhengrong Li、Weiqiang Zhong、Wenxiang Gu

  DOI：10.1055/s-0032-1317683

  日期：——

  polysubstituted furans were synthesized from furan derivatives involving copper-catalyzed ring opening of the furan ring. This synthetic method possesses the advantages of readily available starting materials, mild reaction conditions, and short steps. A range of polysubstituted furans were synthesized from furan derivatives involving copper-catalyzed ring opening of the furan ring. This synthetic

  摘要 从涉及呋喃环的铜催化的开环的呋喃衍生物合成了一系列多取代的呋喃。该合成方法具有容易获得的原料，温和的反应条件和步骤短的优点。 从涉及呋喃环的铜催化的开环的呋喃衍生物合成了一系列多取代的呋喃。该合成方法具有容易获得的原料，温和的反应条件和步骤短的优点。