5-(4-Carboxyphenylmethoxy)-2-(diphenylacetyl) 1,2,3,4-tetrahydro-6-methoxy-3-isoquinolinecarboxylic acid | 152362-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-Carboxyphenylmethoxy)-2-(diphenylacetyl) 1,2,3,4-tetrahydro-6-methoxy-3-isoquinolinecarboxylic acid
• 英文别名: 5-(4-Carboxy-benzyloxy)-2-diphenylacetyl-6-methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid；5-[(4-carboxyphenyl)methoxy]-2-(2,2-diphenylacetyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
• CAS: 152362-62-4
• 化学式: C₃₃H₂₉NO₇
• 分子量: 551.596
• InChiKey: ADYTVTJZRCKUAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  41
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-[(4-Carbomethoxyphenyl)methoxy]-2-(diphenyl acetyl)-1,2,3,4-tetrahydro 6-methoxy-3-isoquinoline carboxylic acid, ethyl ester 在 盐酸 、 乙醚 、 ethyl acetate-petroleum ether 作用下， 以 甲醇 、 sodium hydroxide 为溶剂， 反应 1.0h， 生成 5-(4-Carboxyphenylmethoxy)-2-(diphenylacetyl) 1,2,3,4-tetrahydro-6-methoxy-3-isoquinolinecarboxylic acid
  参考文献：
  名称：

  Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin II receptor

  摘要：

  本发明涉及新型取代的1,2,3,4-四氢异喹啉，其在治疗血管再狭窄、中枢神经系统的各种疾病、调节女性生殖功能、认知增强、动脉粥样硬化以及治疗过度AVP分泌障碍方面有用。本发明还揭示了用于制备该化合物的新型中间体。还揭示了使用该化合物和含有它们的制药组合物的方法。

  公开号：

  US05489686A1

文献信息

• Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor
  申请人：Warner-Lambert Company

  公开号：US05246943A1

  公开（公告）日：1993-09-21

  This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in cognitive enhancement, in atherosclerosis and in treating excessive AVP secretory disorders. Novel intermediates useful in the preparation of the compounds are also disclosed. Methods of using the compounds and pharmaceutical compositions containing them are disclosed.

  本发明涉及新型取代的1,2,3,4-四氢异喹啉，其在治疗血管再狭窄、中枢神经系统的各种疾病、调节女性生殖功能、认知增强、动脉粥样硬化和治疗过度AVP分泌障碍方面有用。还公开了制备该化合物有用的新型中间体。公开了使用该化合物的方法和含有它们的制药组合物。
• METHOD OF TREATMENT OR PROPHYLAXIS INFLAMMATORY PAIN
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：EP1996183A1

  公开（公告）日：2008-12-03
• METHOD OF TREATMENT OR PROPHYLAXIS OF INFLAMMATORY PAIN
  申请人：Smith Maree Therese

  公开号：US20100292159A1

  公开（公告）日：2010-11-18

  This invention discloses the use of angiotensin II receptor 2 (AT 2 receptor) antagonists for the treatment, prophylaxis, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals and particularly in human subjects. The AT 2 receptor antagonists may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory conditions.
• Method of Treatment or Prophylaxis of Inflammatory Pain
  申请人：Spinifex Pharmaceuticals Pty Ltd

  公开号：US20140142116A1

  公开（公告）日：2014-05-22

  A method of treatment, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals, particularly in human subjects, comprising administering angiotensin II receptor 2 (AT 2 receptor) antagonists is disclosed. The AT 2 receptor antagonist may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory pain.
• METHOD OF TREATMENT OR PROPHYLAXIS INFTAMMATORY PAIN
  申请人：Novartis AG

  公开号：US20160052925A1

  公开（公告）日：2016-02-25

  A method of treatment, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals, particularly in human subjects, comprising administering angiotensin II receptor 2 (AT 2 receptor) antagonists is disclosed. The AT 2 receptor antagonist may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory pain.