9-γ-piperidinopropyl-9,10-dihydro-9,10-methanoanthracene | 75987-54-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 9-γ-piperidinopropyl-9,10-dihydro-9,10-methanoanthracene
• 英文别名: 9-gamma-Piperidinopropyl-9,10-dihydro-9,10-methanoanthracene；1-[3-(1-tetracyclo[6.6.1.02,7.09,14]pentadeca-2,4,6,9,11,13-hexaenyl)propyl]piperidine
• CAS: 75987-54-1
• 化学式: C₂₃H₂₇N
• 分子量: 317.474
• InChiKey: BNZBJYGEZCZWSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-piperidin-1-yl-3-(1-tetracyclo[6.6.1.02,7.09,14]pentadeca-2,4,6,9,11,13-hexaenyl)propan-1-one 生成 9-γ-piperidinopropyl-9,10-dihydro-9,10-methanoanthracene
  参考文献：
  名称：

  SUNAGAVA, DZYUN;SATO, XIROMI;KATSUBEH, DZYUNKI;YAMAMOTO, XISAO

  摘要：

  DOI：

文献信息

• Organic tricyclic compounds
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04224344A1

  公开（公告）日：1980-09-23

  Novel 9-aminoalkyl-methanoanthracenes of the formula: ##STR1## wherein A is C.sub.1 -C.sub.4 alkylene or C.sub.3 -C.sub.4 alkenylene and R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.3 -C.sub.6 cycloalkyl(C.sub.1 -C.sub.3)alkyl, ar(C.sub.1 -C.sub.3)alkyl or polyhalo(C.sub.2 -C.sub.4)alkyl or, when taken together with the adjacent nitrogen atom, they may form a 5 to 7-membered nitrogen-containing heterocyclic ring which may contain an additional hetero atom, and their non-toxic salts, which are useful as anti-anxiety, anti-depressant, major tranquilizer, anti-histamine and anti-allergy drugs and can be prepared through a novel key intermediate, i.e., 9-formyl-9,10-dihydro-9,10-methanoanthracene, by various methods.

  新型9-氨基烷基-甲基蒽的化学式为：其中A为C.sub.1 -C.sub.4烷基或C.sub.3 -C.sub.4烯基，R.sub.1和R.sub.2分别为氢、C.sub.1 -C.sub.4烷基、C.sub.3 -C.sub.4烯基、C.sub.3 -C.sub.4炔基、C.sub.3 -C.sub.6环烷基(C.sub.1 -C.sub.3)烷基、ar(C.sub.1 -C.sub.3)烷基或多卤(C.sub.2 -C.sub.4)烷基，或者与相邻氮原子结合时，它们可以形成一个含氮的5至7元杂环，该环可能含有额外的杂原子，以及它们的无毒盐。这些化合物可用作抗焦虑、抗抑郁、镇静剂、抗组织胺和抗过敏药物，并可通过一种新型关键中间体制备，即9-甲酰基-9,10-二氢-9,10-甲基蒽，通过各种方法制备。
• 9-Formyl-9,10-dihydro-9,10-methanoanthracene
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04358620A1

  公开（公告）日：1982-11-09

  Novel 9-aminoalkyl-methanoanthracenes of the formula: ##STR1## wherein A is C.sub.1 -C.sub.4 alkylene or C.sub.3 -C.sub.4 alkenylene and R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.3 -C.sub.6 cycloalkyl(C.sub.1 -C.sub.3)alkyl, ar(C.sub.1 -C.sub.3)alkyl or polyhalo(C.sub.2 -C.sub.4)alkyl or, when taken together with the adjacent nitrogen atom, they may form a 5 to 7-membered nitrogen-containing heterocyclic ring which may contain an additional hetero atom, and their non-toxic salts, which are useful as anti-anxiety, anti-depressant, major tranquilizer, anti-histamine and anti-allergy drugs and can be prepared through a novel key intermediate, i.e. 9-formyl-9,10-dihydro-9,10-methanoanthracene, by various methods.

  公式如下：##STR1## 其中A为C.sub.1-C.sub.4烷基或C.sub.3-C.sub.4烯基，R.sub.1和R.sub.2分别为氢、C.sub.1-C.sub.4烷基、C.sub.3-C.sub.4烯基、C.sub.3-C.sub.4炔基、C.sub.3-C.sub.6环烷基(C.sub.1-C.sub.3)烷基、ar(C.sub.1-C.sub.3)烷基或多卤素(C.sub.2-C.sub.4)烷基，或者与相邻的氮原子一起形成一个含氮杂环的5-7元环，该杂环可以包含一个额外的杂原子，其非毒性盐可用作抗焦虑、抗抑郁、镇静剂、抗组胺和抗过敏药物，可以通过一种新的关键中间体即9-甲酰基-9,10-二氢-9,10-甲基蒽制备。
• US4224344A
  申请人：——

  公开号：US4224344A

  公开（公告）日：1980-09-23
• US4358620A
  申请人：——

  公开号：US4358620A

  公开（公告）日：1982-11-09