(L)-2-[(diphenylphosphino)methyl]pyrrolidine | 815601-62-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (L)-2-[(diphenylphosphino)methyl]pyrrolidine
• 英文别名: 2-(diphenylphosphino)methylpyrrolidine；2-Diphenylphosphino methylpyrrolidine；diphenyl(pyrrolidin-2-ylmethyl)phosphane
• CAS: 815601-62-8
• 化学式: C₁₇H₂₀NP
• 分子量: 269.326
• InChiKey: IWRBGJKCDORZHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  [RhCl2(PPh3)3] 、 (L)-2-[(diphenylphosphino)methyl]pyrrolidine 以 甲苯 为溶剂， 反应 1.5h， 生成
  参考文献：
  名称：

  ALCOHOL PRODUCTION METHOD BY REDUCING ESTER OF LACTONE WITH HYDROGEN

  摘要：

  提供的酒精生产方法包括以下步骤：使用以以下一般式（1）表示的钌配合物作为催化剂，通过氢气还原酯或内酯以产生相应的醇，而无需添加碱性化合物：RuH(X)(L1)(L2)n(1)其中X代表一价阴离子配体，L1代表至少具有一个配位膦基团和至少一个配位氨基团的四齿配体，或者具有一个配位膦基团和一个配位氨基团的双齿氨基膦配体，L2代表具有一个配位膦基团和一个配位氨基团的双齿氨基膦配体，n为0时，L1为四齿配体，n为1时，L1为双齿氨基膦配体。

  公开号：

  US20100063294A1

文献信息

• METHOD FOR PREPARING A METAL CATALYST
  申请人：Abdur-Rashid Kamaluddin

  公开号：US20120046479A1

  公开（公告）日：2012-02-23

  The present disclosure relates to a method for preparing a metal catalyst comprising at least one ligand that is coordinated to the metal through at least one phosphorous (P) atom and at least one nitrogen (N) atom, the method comprising reacting a metal pre-cursor complex with an acid ad salt of an aminophosphine, diaminophosphine, aminodiphosphine or diaminodiphosphine, in the presence of a base.

  本公开涉及一种制备金属催化剂的方法，该方法包括至少一种通过至少一个磷（P）原子和至少一个氮（N）原子配位到金属的配体，所述方法包括在碱的存在下，将金属前体配合物与氨基膦、二氨基膦、氨基双膦或二氨基双膦的酸和盐反应。
• [EN] METHOD FOR PRODUCING AMIDINE DERIVATIVES<br/>[FR] PROCÉDÉ DE PRODUCTION DE DÉRIVÉS D'AMIDINE
  申请人：BIOCRYST PHARM INC

  公开号：WO2016029216A2

  公开（公告）日：2016-02-25

  The invention provides methods and intermediates useful in the synthesis of a compound of formula (I): or a pharmaceutically acceptable salt, solvate, ester or prodrug thereof; wherein the variables are as defined herein.

  本发明提供了用于合成式(I)化合物的方法和中间体，或其药学上可接受的盐、溶剂和前药酯；其中变量如本文所定义。
• ALCOHOL PRODUCTION METHOD BY REDUCING ESTER OR LACTONE WITH HYDROGEN
  申请人：KURIYAMA Wataru

  公开号：US20130006020A1

  公开（公告）日：2013-01-03

  Provided is an alcohol production method comprising the step of reducing an ester or a lactone with hydrogen to produce a corresponding alcohol without addition of a base compound by using, as a catalyst, a ruthenium complex represented by the following general formula (1): RuH(X)(L 1 )(L 2 ) n (1) wherein X represents a monovalent anionic ligand, L 1 represents a tetradentate ligand having at least one coordinating phosphino group and at least one coordinating amino group or a bidentate aminophosphine ligand having one coordinating phosphino group and one coordinating amino group, and L 2 represents a bidentate aminophosphine ligand having one coordinating phosphino group and one coordinating amino group, provided that n is 0 when L 1 is the tetradentate ligand, and n is 1 when L 1 is the bidentate aminophosphine ligand.

  提供了一种酒精生产方法，包括以下步骤：使用以铑复合物为催化剂，通过氢气还原酯或内酯以产生相应的醇，而无需添加碱性化合物。所述铑复合物由下列通式（1）表示： RuH（X）（L1）（L2）n（1） 其中，X代表单价阴离子配体，L1代表具有至少一个配位膦基团和至少一个配位氨基团的四配位配体或具有一个配位膦基团和一个配位氨基团的双配位氨基膦配体，L2代表具有一个配位膦基团和一个配位氨基团的双配位氨基膦配体，当L1为四配位配体时，n为0，当L1为双配位氨基膦配体时，n为1。
• Alcohol production method by reducing ester or lactone with hydrogen
  申请人：Takasago International Corporation

  公开号：EP2161251A1

  公开（公告）日：2010-03-10

  Provided is an alcohol production method comprising the step of reducing an ester or a lactone with hydrogen to produce a corresponding alcohol without addition of a base compound by using, as a catalyst, a ruthenium complex represented by the following general formula (1):          RuH(X)(L1)(L2)n     (1) wherein X represents a monovalent anionic ligand, L1 represents a tetradentate ligand having at least one coordinating phosphino group and at least one coordinating amino group or a bidentate aminophosphine ligand having one coordinating phosphino group and one coordinating amino group, and L2 represents a bidentate aminophosphine ligand having one coordinating phosphino group and one coordinating amino group, provided that n is 0 when L1 is the tetradentate ligand, and n is 1 when L1 is the bidentate aminophosphine ligand.

  本发明提供了一种醇类生产方法，该方法包括以下步骤：使用通式 (1) 所代表的钌络合物作为催化剂，用氢气还原酯或内酯，从而在不添加碱化合物的情况下生成相应的醇： RuH(X)(L1)(L2)n (1) 其中 X 代表一价阴离子配体、 L1 代表具有至少一个配位膦基和至少一个配位氨基的四价配体或具有一个配位膦基和一个配位氨基的双价氨基膦配体，以及 L2 代表具有一个配位膦基和一个配位氨基的双叉氨基膦配体，条件是 当 L1 为四价配体时，n 为 0；当 L1 为双价氨基膦配体时，n 为 1。
• PRACTICAL METHOD FOR REDUCING ESTERS OR LACTONES
  申请人：Tokyo Institute of Technology

  公开号：EP2298723A1

  公开（公告）日：2011-03-23

  Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H2). An extremely practical reduction method can be provided by preferable combinations of the Group 8 (VIII) transition metal complex, the base, a used amount of the base, a pressure of hydrogen gas and a reaction temperature. This method is used in place of hydride reduction and is a useful method by which design of highly active catalysts can be relatively easily made while a high productivity can be expected.

  在第 8 (VIII) 族过渡金属络合物、碱和氢气 (H2) 的存在下，酯和内酯可分别还原成醇和二元醇。8 (VIII)族过渡金属络合物、碱、碱的用量、氢气的压力和反应温度的最佳组合可以提供一种极为实用的还原方法。这种方法可代替氢化物还原法，是一种有用的方法，可以相对容易地设计出高活性催化剂，同时可望获得较高的生产率。