1-[(2R,3S,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-4-ethoxy-2-oxo-1,2-dihydro-pyrimidine-5-carboxylic acid diethylamide | 129436-38-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 吡咯并嘧啶核苷和核苷酸
• 英文名称: 1-[(2R,3S,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-4-ethoxy-2-oxo-1,2-dihydro-pyrimidine-5-carboxylic acid diethylamide
• 英文别名: 1-[(2R,3S,4R,5R)-3,4-bis[[tert-butyl(dimethyl)silyl]oxy]-5-[[tert-butyl(dimethyl)silyl]oxymethyl]oxolan-2-yl]-4-ethoxy-N,N-diethyl-2-oxopyrimidine-5-carboxamide
• CAS: 129436-38-0
• 化学式: C₃₄H₆₇N₃O₇Si₃
• 分子量: 714.178
• InChiKey: XXLUTEVAATZEBA-KMFVSHEXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.82
• 重原子数：
  47
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  99.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-[(2R,3S,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-4-ethoxy-2-oxo-1,2-dihydro-pyrimidine-5-carboxylic acid diethylamide 生成 1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-ethoxy-2-oxo-1,2-dihydro-pyrimidine-5-carboxylic acid diethylamide
  参考文献：
  名称：

  Dynamic aspects in the LDA lithiation of an arabinofuranosyl derivative of 4-ethoxy-2-pyrimidinone: Regioselective entry to both C-5 and C-6 substitutions

  摘要：

  DOI：

  10.1016/s0040-4039(00)88789-4
• 作为产物：
  描述：

  1-<2,3,5-Tris-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl>-4-ethoxy-2-pyrimidone 、 N,N-二乙基氯甲酰胺 在 lithium diisopropyl amide 作用下， 生成 1-[(2R,3S,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-4-ethoxy-2-oxo-1,2-dihydro-pyrimidine-5-carboxylic acid diethylamide
  参考文献：
  名称：

  Dynamic aspects in the LDA lithiation of an arabinofuranosyl derivative of 4-ethoxy-2-pyrimidinone: Regioselective entry to both C-5 and C-6 substitutions

  摘要：

  DOI：

  10.1016/s0040-4039(00)88789-4

文献信息

• SHIMIZU, MIHO;TANAKA, HIROMICHI;HAYAKAWA, HIROYUKI;MIYASAKA, TADASHI, TETRAHEDRON LETT., 31,(1990) N, C. 1295-1298
  作者：SHIMIZU, MIHO、TANAKA, HIROMICHI、HAYAKAWA, HIROYUKI、MIYASAKA, TADASHI

  DOI：——

  日期：——