methyl 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbonyl] phenylsulfone | 120081-56-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbonyl] phenylsulfone
• 英文别名: (4-Methylsulfonylphenyl)-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)methanone
• CAS: 120081-56-3
• 化学式: C₂₂H₂₆O₃S
• 分子量: 370.513
• InChiKey: MJCGVYAGZVLLCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl) hydroxymethyl]phenylsulfone 生成 methyl 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbonyl] phenylsulfone
  参考文献：
  名称：

  MAIGNAN, JEAN;LARG, GERARD;MALLE, GERARD;RESTLE, SERGE

  摘要：

  DOI：

文献信息

• Aromatic polycyclic derivatives, their process of preparation and their
  申请人：Societe Anonyme dite: L'Oreal

  公开号：US04980509A1

  公开（公告）日：1990-12-25

  An aromatic polycyclic compound has the formula ##STR1## wherein R represents --SO.sub.3 H, SO.sub.2 NHR.sub.3, ##STR2## --SO.sub.2 R.sub.3, --SOR.sub.3 or --SR.sub.3, R.sub.3 represents lower alkyl, monohydroxyalkyl, polyhydroxyalkyl, aminoalkyl, carboxyalkyl, aminocarboxyalkyl or alkoxyalkyl, R' represents hydrogen, lower alkyl, lower alkoxy, hydroxy, C.sub.1 -C.sub.4 acyloxy or amino, R" represents hydrogen, lower alkyl or lower alkoxy, or R' and R", taken together, form an oxo, methano or hydroxyimino radical, R.sub.1 represents hydrogen or lower alkyl, n is 0 or 1, when n=1, R.sub.2 represents hydrogen or lower alkyl, or R.sub.1 and R.sub.2, taken together form a vinylene radical, and Ar represents an aromatic radical selected from ##STR3## wherein R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 represent hydrogen or lower alkyl, at least one of R.sub.4 and/or R.sub.5 being other than hydrogen, and at least two of R.sub.8 -R.sub.11 being other than hydrogen, A represents methylene or dimethylene substituted or not by lower alkyl; when A represents dimethylene, R.sub.8 and R.sub.10 together can form a methylene or dimethylene radical, and the salts of the compound of formula I as well as their geometric and optical isomers. These compounds are useful in human and veterinary medicines and in cosmetic compositions.

  一种芳香多环化合物的化学式为##STR1##其中R代表--SO.sub.3 H, SO.sub.2 NHR.sub.3, ##STR2## --SO.sub.2 R.sub.3, --SOR.sub.3或--SR.sub.3，R.sub.3代表低碳烷基，单羟基烷基，多羟基烷基，氨基烷基，羧基烷基，氨基羧基烷基或烷氧基烷基，R'代表氢，低碳烷基，低烷氧基，羟基，C.sub.1 -C.sub.4酰氧基或氨基，R"代表氢，低碳烷基或低烷氧基，或R'和R"结合在一起形成氧代、甲基或羟亚胺基团，R.sub.1代表氢或低碳烷基，n为0或1，当n=1时，R.sub.2代表氢或低碳烷基，或R.sub.1和R.sub.2结合在一起形成乙烯基团，Ar代表从##STR3##中选择的芳香基团，其中R.sub.4，R.sub.5，R.sub.6，R.sub.7，R.sub.8，R.sub.9，R.sub.10和R.sub.11代表氢或低碳烷基，至少一个R.sub.4和/或R.sub.5不是氢，至少两个R.sub.8 -R.sub.11不是氢，A代表亚甲基或二亚甲基，可以由低碳烷基取代或不取代；当A代表二亚甲基时，R.sub.8和R.sub.10可以共同形成亚甲基或二亚甲基基团，以及化合物I的盐及其几何和光学异构体。这些化合物在人类和兽医药物以及化妆品组合物中有用。
• Nouveaux dérivés polycycliques aromatiques, leur procédé de préparation et leur utilisation en médecine humaine et vétérinaire et en cosmétique
  申请人：L'OREAL

  公开号：EP0297995B1

  公开（公告）日：1991-03-06
• US4980509A
  申请人：——

  公开号：US4980509A

  公开（公告）日：1990-12-25