N-1-(β-Aminoethyl)-N-4-benzyl-<α-(4-chlorphenyl)>-piperazin | 19178-78-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-1-(β-Aminoethyl)-N-4-benzyl-<α-(4-chlorphenyl)>-piperazin
• 英文别名: 1-(2-aminoethyl)-4-[α-(4-chlorophenyl)benzyl]-piperazine；N-(p-chlorobenzhydryl)-N'-(2-aminoethyl)piperazine；2-[4-(4-chloro-benzhydryl)-piperazin-1-yl]-ethylamine；4-(4-Chlorobenzhydryl)piperazin-1-ylethylamine；2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethanamine
• CAS: 19178-78-0
• 化学式: C₁₉H₂₄ClN₃
• 分子量: 329.873
• InChiKey: XNNAIIZEFLDAEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  32.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-1-(β-Aminoethyl)-N-4-benzyl-<α-(4-chlorphenyl)>-piperazin 、 3,5-二叔丁基-4-羟基肉桂酸 生成 (Z)-but-2-enedioic acid;(E)-N-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethyl]-3-(3,5-ditert-butyl-4-hydroxyphenyl)prop-2-enamide
  参考文献：
  名称：

  OEH, TAKANORI;KAVASAKI, KODZUYUKI;OTI, XIROSI;TEHRADZAVA, MITIO

  摘要：

  DOI：

文献信息

• Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient
  申请人：TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION

  公开号：EP0157420A2

  公开（公告）日：1985-10-09

  According to the invention, there are provided novel amide derivatives and 5-lipoxygenase inhibitors containing the same as an effective ingredient. The above-mentioned compounds of the invention have been demonstrated to possess 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC4 and LTD4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.

  根据本发明，提供了新型酰胺衍生物和以酰胺衍生物为有效成分的 5-脂氧合酶抑制剂。 上述本发明化合物已被证实具有 5-脂氧合酶抑制活性。 这些化合物可以通过抑制 5-脂氧合酶的活性来抑制白三烯（如 LTC4 和 LTD4）的产生，而白三烯是过敏诱因。 因此，酰胺衍生物可用作 5-脂氧合酶抑制剂，对过敏性哮喘、过敏性鼻炎等有效。
• Thiazolidinecarboxylic acid amide derivatives having anti-allergic activity, their preparation and their use
  申请人：Sankyo Company Limited

  公开号：EP0463873A1

  公开（公告）日：1992-01-02

  Compounds of formula (I): [in which R¹ is optionally substituted pyridyl; R² is hydrogen, alkyl or optionally substituted pyridyl; R³ is hydrogen or various organic groups; R⁴ is hydrogen or alkyl; A is alkylene; and Z is a substituted piperidyl, piperazinyl or homopiperazinyl group which is substituted at least by a di-substituted methyl, methoxy or methylene group, each substituent being phenyl or heterocyclyl]; and pharmaceutically acceptable salts thereof have anti-allergic, anti-asthma and anti-PAF activities. Methods of making the compounds are also provided.

  式(I)化合物： [其中 R¹ 是任选取代的吡啶基；R² 是氢、烷基或任选取代的吡啶基；R³ 是氢或各种有机基团；R⁴ 是氢或烷基；A 是亚烷基；和 Z 是至少被二取代甲基、甲氧基或亚甲基取代的取代哌啶基、哌嗪基或均哌嗪基，每个取代基都是苯基或杂环基]；其药学上可接受的盐类具有抗过敏、抗哮喘和抗PAF 活性。还提供了制造这些化合物的方法。
• Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof
  申请人：Korea Institute of Science and Technology

  公开号：EP1757590B1

  公开（公告）日：2009-12-02
• US4673684A
  申请人：——

  公开号：US4673684A

  公开（公告）日：1987-06-16
• US5470851A
  申请人：——

  公开号：US5470851A

  公开（公告）日：1995-11-28