N-tert-butyl-bis-(2-hydroxypropyl)amine | 4203-80-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-tert-butyl-bis-(2-hydroxypropyl)amine
• 英文别名: 1.1'-tert.-Butylamino-dipropanol-2；tert.-Butyl-bis-<2-hydroxypropyl>-amin；tert.Butyl-bis-<2-hydroxy-propyl-(1)>-amin；tert-butyl-bis-(2-hydroxy-propyl)-amine；N-t-butyl-bis-(2-hydroxypropyl)amine；1-[tert-butyl(2-hydroxypropyl)amino]propan-2-ol
• CAS: 4203-80-9
• 化学式: C₁₀H₂₃NO₂
• 分子量: 189.298
• InChiKey: PCRSGENJQANRNB-UHFFFAOYSA-N

物化性质

• 沸点：
  122 °C(Press: 3.0 Torr)
• 密度：
  0.962±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-tert-butyl-bis-(2-hydroxypropyl)amine 在 ruthenium trichloride 、 三苯基膦 苄叉丙酮 作用下， 以 various solvent(s) 为溶剂， 以56%的产率得到3,4-dihydro-4-t-butyl-2,6-dimethyl-2H-1,4-oxazine
  参考文献：
  名称：

  Ruthenium-catalyzed synthesis of substituted 2-hydroxymorpholines and substituted morpholines

  摘要：

  The reaction of primary amines with peroxides afforded substituted hydroxymorpholines which were then converted to substituted morpholines via dihydrooxazines as intermediates. The reaction appears to proceed through a ruthenium-catalyzed dehydrogenation-cyclization process.

  DOI：

  10.1016/s0040-4039(00)91563-6
• 作为产物：
  描述：

  叔丁胺 、 methyloxirane 以 乙醇 为溶剂， 生成 N-tert-butyl-bis-(2-hydroxypropyl)amine
  参考文献：
  名称：

  空间位阻烷基对配合物稳定性影响的结构和热力学研究

  摘要：

  随着N-烷基取代基的大部分沿着甲基，乙基，异丙基，叔丁基系列增加，已经检查了对络合物在水溶液中的热力学稳定性的空间效应和诱导效应之间的平衡。配体7,16-二异丙基-1,4,10,13-四氧杂-7,16-二氮杂环十八烷（L 3）和RN [CH 2 CH（CH 3）OH] 2（R = Me，L 4 ;镨我，L 5 ;或卜吨，L 6）已经被制备。这些配体以及其他具有庞大N烷基的配体的形成常数已通过金属离子Cu II，Zn II确定，Cd II，Pb II以及Ca II，Sr II和Ba II（仅L 3）。配体L 3的N-异丙基会引起所有金属离子的热力学复合物稳定性急剧下降，而在L 2 –L 4系列中，铅（II）在响应感应性时表现出复合物稳定性的强烈增加是不寻常的较大烷基的影响。为了理解通过L 3的N-异丙基降低的配合物稳定性，测定了配合物[KL 3 ] I的晶体结构：单斜，空间群P 2。1 / c，

  DOI：

  10.1039/dt9910002717

文献信息

• SYNTHESIS OF N-SUBSTITUTED DIISOPROPANOLAMINES, THEIR SEBACATE POLYESTERS AND POLYURETHANE ELASTOMERS
  作者：Jean L. Boivin

  DOI：10.1139/v58-206

  日期：1958.10.1

  Several N-substituted diisopropanolamines were prepared by reacting aqueous solutions of amines with excess propylene oxide at ordinary pressure but higher N-substituted diisopropanolamines had to be prepared in an autoclave at 200 °C. The ionization constants of these bases were measured and recorded as pK_a values. Their infrared absorption spectra gave bands common to all diisopropanolamines mainly at 3.04, 7.14, 7.55, 7.85, 9.45, 10.6, and 11.95 microns. Their condensation with sebacic acid gave the corresponding polyesters, which were soluble in strong acids and had molecular weights of about 1500. The hydroxyl-terminated polyesters were cured with a slight excess of 2,4-tolylene diisocyanate at 100 °C for 2 days to yield elastomers of brittle temperatures in the region of −50 °C.

  通过在常压下，将胺的水溶液与过量的丙烯氧基反应，制备了几种N-取代二异丙醇胺。但是，较高的N-取代二异丙醇胺必须在200°C的高压釜中制备。这些碱的解离常数被测量并记录为pK_a值。它们的红外吸收光谱显示出所有二异丙醇胺共有的频带，主要在3.04、7.14、7.55、7.85、9.45、10.6和11.95微米处。它们与癸二酸的缩聚产物是相应的聚酯，溶解在强酸中，分子量约为1500。羟基终止的聚酯在100°C下与轻微过量的2,4-甲苯二异氰酸酯固化2天，形成具有脆性温度在-50°C左右的弹性体。
• Process for preparing oxazine derivatives
  申请人：Texaco Chemical Company

  公开号：US04910303A1

  公开（公告）日：1990-03-20

  This invention relates to the reaction of N-alkyl-bis-(2-hydroxyalkyl)amines to form oxazine derivatives by a process comprising reacting said amines in the presence of a ruthenium-containing compound and hydrogen acceptor.

  本发明涉及使用含钌化合物和氢受体的方法，通过反应N-烷基双（2-羟基烷基）胺来形成噁唑啉衍生物。
• Alkyl-2,3-epoxypropylamines
  作者：V.R. Gaertner

  DOI：10.1016/0040-4020(67)80045-0

  日期：1967.5

  An improved procedure yielded new alkyl-2,3-epoxypropylamines (2), ranging from very unstable (n-alkyl) to exceptionally stable (t-alkyl)types. Kinetics and other data relating to the stabilities of2 are discussed.

  改进的程序产生了新的烷基-2，3-环氧丙胺（2），其范围从非常不稳定的（正烷基）到异常稳定的（叔烷基）类型。讨论了与2的稳定性有关的动力学和其他数据。
• Elasthane threads, their production and intermediate products required
  申请人：Bayer Aktiengesellschaft

  公开号：US04725636A1

  公开（公告）日：1988-02-16

  In the production of elasthane threads by solution spinning of polyurea polyurethanes by conventional spinning processes, excellent stabilization against light and noxious gases are obtained if at least one component of the system to be spun contains tertiary amino groups and the substances used as antioxidizing agents are phenols of the kind which do not form colored nitro compounds.

  在传统纺纱工艺中，通过聚氨酯溶液纺丝生产弹性纱线时，如果所要纺丝的体系中至少有一种成分含有三级胺基，并且作为抗氧化剂使用的物质是不形成有色硝基化合物的苯酚，则可以获得对光和有害气体的良好稳定性。
• Process for preparing hydroxymorpholines and morpholines
  申请人：TEXACO DEVELOPMENT CORPORATION

  公开号：EP0262307A2

  公开（公告）日：1988-04-06

  This invention relates to the reaction of aliphatic epoxides and primary amines to form hydroxymorpholines or morpholines by a process comprising reacting said epoxide and primary amine in the presence of a ruthenium-containing compound, preferably plus a tertiary phosphine.

  本发明涉及脂肪族环氧化物和伯胺反应生成羟基吗啉或吗啉的工艺，该工艺包括在含钌化合物（最好加上叔膦化合物）的存在下使所述环氧化物和伯胺反应。