5H-<1>benzopyrano<4,3-b>pyridine | 29767-29-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5H-<1>benzopyrano<4,3-b>pyridine
• 英文别名: 5H-Benzopyranno<1><4,3-b>pyridine；Chromeno[4,3-b]pyridine；5H-chromeno[4,3-b]pyridine
• CAS: 29767-29-1
• 化学式: C₁₂H₉NO
• mdl: MFCD18450585
• 分子量: 183.21
• InChiKey: IODYDGPSYXFNSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-(2-carbamoylphenoxy)prop-1-yne 在 乙醇 、 氨 、 sodium ethanolate 、 triethyloxonium fluoroborate 作用下， 以 乙醇 、 硝基苯 为溶剂， 反应 6.5h， 生成 5H-<1>benzopyrano<4,3-b>pyridine
  参考文献：
  名称：

  Intramolecular Diels-Alder reactions of pyrimidines and a computational study toward their structure and reactivity

  摘要：

  The syntheses of 2-[(prop-2-ynyloxy)carbonyl]pyrimidine (1), 5-[(prop-2-ynyloxy)carbonyl]pyrimidine (2), 5-phenyl-2-[2-(1-prop-2-ynylpyrryl)]pyrimidine (8),5-phenyl-2-[2-(1-prop-2-ynylpyrrolidinyl)]pyrimidine (9) and 2-[2-(prop-2-ynyloxy)phenyl]-4,6-R2-5-R1-pyrimidine (R1 = H, Cl, Ph; R2 = H, Me) (14a-d) are described. Upon heating, the compounds 1, 9, and 14 undergo an intramolecular Diels-Alder reaction and a subsequent retro Diels-Alder reaction to yield the annelated pyridines 15, 16, and 17, respectively. The compounds 2 and 8 did not react. The nonreactivity of the compounds 2 and 8 is ascribed to conjugation of the pyrimidine aromatic system with part of the dienophilic side chain, giving rise to conformations in which the diene and dienophile moieties cannot interact. For the compounds 1, 9, and 14 conjugation is absent, due to steric hindrance. To support this, semiempirical (MDNO-PM3) and molecular mechanics (MMX, CHEMX) calculations were performed. The HOMO-LUMO energy separation of the compounds did not consequently reflect the observed reactivity. However, the probability of the compounds to be in a reactive conformation appeared to correlate with the observed rate of reaction (9 > 14a > 1 >> 2, 8).

  DOI：

  10.1021/jo00037a011

文献信息

• Synthèse de benzopyrannopyridines et de dihydrobenzoquinoléines
  作者：Marie-Claude Bellassoued-Fargeau、Pierre Maitte

  DOI：10.1002/jhet.5570210561

  日期：1984.9

  La cycloaddition thermique d'un système α-énone avec l'oxyde de vinyle et d'éthyle conduit à un éthoxy-2 dihydropyranne aisément transformé en pyridine par action du chlorhydrate d'hydroxylamine. Ce schéma réactionnel a permis de réaliser la synthèse de benzopyrannopyridines et de dihydrobenzoquinoléines.

  环加成体系的热电联产乙烯和乙氧基的环氧乙烷和乙氧基-2二氢吡喃通道的吡啶转化为氯水合羟胺的吡啶。可以与苯并吡喃基吡啶和二氢苯并喹啉类化合物合用。
• BELLASSOUED-FARGEAU, M. -C.;MAITTE, P., J. HETEROCYCL. CHEM., 1984, 21, N 5, 1549-1552
  作者：BELLASSOUED-FARGEAU, M. -C.、MAITTE, P.

  DOI：——

  日期：——
• Intramolecular Diels-Alder reactions of pyrimidines and a computational study toward their structure and reactivity
  作者：Werner A. W. Stolle、August E. Frissen、Antonius T. M. Marcelis、Henk C. Van der Plas

  DOI：10.1021/jo00037a011

  日期：1992.5

  The syntheses of 2-[(prop-2-ynyloxy)carbonyl]pyrimidine (1), 5-[(prop-2-ynyloxy)carbonyl]pyrimidine (2), 5-phenyl-2-[2-(1-prop-2-ynylpyrryl)]pyrimidine (8),5-phenyl-2-[2-(1-prop-2-ynylpyrrolidinyl)]pyrimidine (9) and 2-[2-(prop-2-ynyloxy)phenyl]-4,6-R2-5-R1-pyrimidine (R1 = H, Cl, Ph; R2 = H, Me) (14a-d) are described. Upon heating, the compounds 1, 9, and 14 undergo an intramolecular Diels-Alder reaction and a subsequent retro Diels-Alder reaction to yield the annelated pyridines 15, 16, and 17, respectively. The compounds 2 and 8 did not react. The nonreactivity of the compounds 2 and 8 is ascribed to conjugation of the pyrimidine aromatic system with part of the dienophilic side chain, giving rise to conformations in which the diene and dienophile moieties cannot interact. For the compounds 1, 9, and 14 conjugation is absent, due to steric hindrance. To support this, semiempirical (MDNO-PM3) and molecular mechanics (MMX, CHEMX) calculations were performed. The HOMO-LUMO energy separation of the compounds did not consequently reflect the observed reactivity. However, the probability of the compounds to be in a reactive conformation appeared to correlate with the observed rate of reaction (9 > 14a > 1 >> 2, 8).