ε(4-nitro 2-methoxy benzenesulfonamido)caproic acid | 85844-92-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ε(4-nitro 2-methoxy benzenesulfonamido)caproic acid
• 英文别名: epsilon(4-Nitro 2-methoxy-benzenesulfonamido)caproic acid；6-[(2-methoxy-4-nitrophenyl)sulfonylamino]hexanoic acid
• CAS: 85844-92-4
• 化学式: C₁₃H₁₈N₂O₇S
• 分子量: 346.361
• InChiKey: SHZOGHKEJLKFNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  147
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  ε(4-nitro 2-methoxy benzenesulfonamido)caproic acid 生成 epsilon(4-Amino 2-methoxy-benzenesulfonamido)caproic acid
  参考文献：
  名称：

  CHOAY, P.;ROGER, P.;OLLIERO, D.

  摘要：

  DOI：

文献信息

• Arylbenzenesulfonamide containing pharmaceutical compositions
  申请人：Dropic, Societe civile de gestion de droits de propriete industrielle

  公开号：US04761430A1

  公开（公告）日：1988-08-02

  The invention relates to new medicaments having lipid regulating properties nd processes for their preparation. The medicaments according to the invention contain as active principle at least one compound, (or its corresponding optical isomer) of the arylsulfonamide type corresponding to the formula: ##STR1## in which: Ar prepresents an aromatic ring which may if necessary be substituted; n+m+1 is comprised from 3 to 11, being preferably equal to 3, 5 or 10; R.sub.5 and R.sub.6 represent independently of one another, particularly an alkyl radical; R.sub.4 represents the hydroxy group, the radical OR.sub.7 in which R.sub.7 is particularly an alkyl group, the radical NR.sub.8 R.sub.9 in which R.sub.8 and R.sub.9 are identical or different, and represent in particular a hydrogen atom, and form with the nitrogen a nitrogenous heterocyclic ring with 5 or 6 links.

  本发明涉及具有调节脂质的新药物及其制备方法。根据本发明，所述药物包含至少一种芳基磺酰胺型化合物（或其相应的光学异构体）作为活性成分，其化学式为：##STR1## 其中：Ar代表若必要可以被取代的芳香环；n+m+1的值在3到11之间，最好等于3、5或10；R.sub.5和R.sub.6各自独立地代表特别是烷基基团；R.sub.4代表羟基、基团OR.sub.7，其中R.sub.7特别是烷基团，基团NR.sub.8R.sub.9，其中R.sub.8和R.sub.9相同或不同，特别是代表氢原子，并与氮形成含5或6个链的氮杂环。
• Method for treating disorders of lipid metabolism using benzene
  申请人：Choay S.A.

  公开号：US04613618A1

  公开（公告）日：1986-09-23

  The invention relates to new medicaments having lipid regulating properties and processes for their preparation. The medicaments according to the invention contain as active principle at least one compound, (or its corresponding optical isomer) of the arylsulfonamide type corresponding to the formula: ##STR1## in which: Ar represents an aromatic ring which may if necessary be substituted; n+m+1 is comprised from 3 to 11, being preferably equal to 3,5 or 10, or is comprised from 1 to 11 when Ar represents an aryl group in which at least one of the R.sub.1,R.sub.2 and R.sub.3 radicals is a CF.sub.3 group; R.sub.5 and R.sub.6 represent independently of one another particularly an alkyl radical; R.sub.4 represents the hydroxy group, the radical OR.sub.7 in which R.sub.7 is particularly an alkyl group, the radical NR.sub.8 R.sub.9 in which R.sub.8 and R.sub.9 are identical or different, and represent in particular a hydrogen atom, and form with the nitrogen a nitrogenous heterocyclic ring with 5 or 6 links.

  本发明涉及具有调节脂质作用的新药物及其制备方法。本发明的药物包含至少一种芳基磺酰胺类化合物（或其对应的光学异构体）作为活性成分，其化学式为：##STR1## 其中：Ar代表可能被取代的芳香环；n+m+1为3到11之间，最好等于3、5或10；或当Ar代表至少一个R.sub.1、R.sub.2和R.sub.3基团为CF.sub.3基团的芳基基团时，n+m+1为1到11之间；R.sub.5和R.sub.6相互独立，特别地是烷基基团；R.sub.4代表羟基，基团OR.sub.7，其中R.sub.7特别是烷基基团，基团NR.sub.8R.sub.9，其中R.sub.8和R.sub.9相同或不同，特别是氢原子，并与氮形成含5或6个链的氮杂环。
• US4613618A
  申请人：——

  公开号：US4613618A

  公开（公告）日：1986-09-23
• US4761430A
  申请人：——

  公开号：US4761430A

  公开（公告）日：1988-08-02