(8S,9S,11S,13S,14S,17S)-13-methyl-11-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-17-phenylmethoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol | 1107638-10-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (8S,9S,11S,13S,14S,17S)-13-methyl-11-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-17-phenylmethoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
• CAS: 1107638-10-7
• 化学式: C₃₉H₅₃F₅O₃S
• 分子量: 696.906
• InChiKey: VDQHKBZVIJEOPW-ORTHZKLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.1
• 重原子数：
  48
• 可旋转键数：
  17
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  65.7
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (8S,9S,11S,13S,14S,17S)-13-methyl-11-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-17-phenylmethoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol 在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以56%的产率得到3,17β-dihydroxy-11β-[9-(4,4,5,5,5-pentafluoropentane-1-sulfinyl)nonyl]-estra-1,3,5(10)-triene
  参考文献：
  名称：

  Effect of Fluorination on the Pharmacological Profile of 11β Isomers of Fulvestrant in Breast Carcinoma Cells

  摘要：

  We describe the synthesis of an 11 beta isomer 3 of the steroidal antiestrogen fulvestrant 2. Partial fluorination of the 11 beta side chain in 3 leads to 4, which still shows strong antiproliferative activity on MCF-7 cells. However, unlike 2 and 3, compound 4 fails to down-regulate estrogen receptor alpha (ER alpha). This result suggests that ER alpha down-regulation is not a sine qua non condition for the antitumor activity of steroidal antiestrogens.

  DOI：

  10.1021/jm801154q
• 作为产物：
  描述：

  3,17β-bisbenzyloxy-11β-[9-(4,4,5,5,5-pentafluoropentane-1-sulfinyl)non-3-enyl]estra-1,3,5(10)-triene 在 氢气 、 palladium(II) hydroxide 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 以68%的产率得到(8S,9S,11S,13S,14S,17S)-13-methyl-11-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-17-phenylmethoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
  参考文献：
  名称：

  Effect of Fluorination on the Pharmacological Profile of 11β Isomers of Fulvestrant in Breast Carcinoma Cells

  摘要：

  We describe the synthesis of an 11 beta isomer 3 of the steroidal antiestrogen fulvestrant 2. Partial fluorination of the 11 beta side chain in 3 leads to 4, which still shows strong antiproliferative activity on MCF-7 cells. However, unlike 2 and 3, compound 4 fails to down-regulate estrogen receptor alpha (ER alpha). This result suggests that ER alpha down-regulation is not a sine qua non condition for the antitumor activity of steroidal antiestrogens.

  DOI：

  10.1021/jm801154q

文献信息

• Effect of Fluorination on the Pharmacological Profile of 11β Isomers of Fulvestrant in Breast Carcinoma Cells
  作者：Vangelis Agouridas、Emmanuel Magnier、Jean-Claude Blazejewski、Ioanna Laïos、Anny Cleeren、Denis Nonclercq、Guy Laurent、Guy Leclercq

  DOI：10.1021/jm801154q

  日期：2009.2.12

  We describe the synthesis of an 11 beta isomer 3 of the steroidal antiestrogen fulvestrant 2. Partial fluorination of the 11 beta side chain in 3 leads to 4, which still shows strong antiproliferative activity on MCF-7 cells. However, unlike 2 and 3, compound 4 fails to down-regulate estrogen receptor alpha (ER alpha). This result suggests that ER alpha down-regulation is not a sine qua non condition for the antitumor activity of steroidal antiestrogens.