2-(2-methoxyphenyl)-N,N',4-trimethyl-1H-phenothiazine-1,3-dicarboxamide | 1119816-02-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 2-(2-methoxyphenyl)-N,N',4-trimethyl-1H-phenothiazine-1,3-dicarboxamide
• 英文别名: 2-(2-Methoxyphenyl)-N,N'',4-trimethyl-10Hphenothiazine-1,3-dicarboxamide；2-(2-methoxyphenyl)-1-N,3-N,4-trimethyl-10H-phenothiazine-1,3-dicarboxamide
• CAS: 1119816-02-2
• 化学式: C₂₄H₂₃N₃O₃S
• 分子量: 433.531
• InChiKey: SGLCGLLOKYJDBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(2-methoxyphenyl)-N,N',4-trimethyl-6-[(2-mercaptophenyl)amino]cyclohexa-3,5-diene-1,3-dicarboxamide 以 二甲基亚砜 为溶剂， 反应 5.0h， 以31%的产率得到2-(2-methoxyphenyl)-N,N',4-trimethyl-2,10-dihydro-1H-phenothiazine-1,3-dicarboxamide
  参考文献：
  名称：

  10H-Phenothiazines: A new class of enzyme inhibitors for inflammatory diseases

  摘要：

  The phenothiazine nucleus is known for their inhibitory activity towards the regulatory enzymes that are contributing to diseases such as asthma, autoimmune diseases including allergic rheumatoid and encephalomyelitis. In this study a number of substituted phenothiazines were synthesized and screened for their biological activity against the regulatory enzymes involved in inflammatory diseases. Our results show that the newly synthesized compounds 4a-c and 5a-c exhibited promising target specific enzyme inhibition against phosphodiesterase, prostaglandin dehydrogenase and superoxide dismutase activity depending on steric factors of the molecules. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.02.028

文献信息

• 10H-Phenothiazines: A new class of enzyme inhibitors for inflammatory diseases
  作者：Y.S. Sadanandam、Meera M. Shetty、A. Bhaskar Rao、Y. Rambabu

  DOI：10.1016/j.ejmech.2008.02.028

  日期：2009.1

  The phenothiazine nucleus is known for their inhibitory activity towards the regulatory enzymes that are contributing to diseases such as asthma, autoimmune diseases including allergic rheumatoid and encephalomyelitis. In this study a number of substituted phenothiazines were synthesized and screened for their biological activity against the regulatory enzymes involved in inflammatory diseases. Our results show that the newly synthesized compounds 4a-c and 5a-c exhibited promising target specific enzyme inhibition against phosphodiesterase, prostaglandin dehydrogenase and superoxide dismutase activity depending on steric factors of the molecules. (C) 2008 Elsevier Masson SAS. All rights reserved.