3-Chloro-4'-methyl-diphenylether | 89869-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Chloro-4'-methyl-diphenylether
• 英文别名: 1-Chloro-3-(4-methylphenoxy)benzene
• CAS: 89869-16-9
• 化学式: C₁₃H₁₁ClO
• 分子量: 218.683
• InChiKey: LUCLQMOGUYTWGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-Chloro-4'-methyl-diphenylether 在 sodium hydroxide 、 三氯化铝 、 双氧水 、 三氯化磷 作用下， 生成 7-chloro-2-methyl-10-hydroxy-10H-phenoxaphosphine-10-oxide 、 1-chloro-8-methyl-10-hydroxy-10H-phenoxaphosphine-10-oxide
  参考文献：
  名称：

  Renger, Bernd, Journal of Heterocyclic Chemistry, 1983, vol. 20, p. 1601 - 1603

  摘要：

  DOI：
• 作为产物：
  描述：

  间氯溴苯 、 对甲酚 以36%的产率得到
  参考文献：
  名称：

  RENGER, B., J. HETEROCYCL. CHEM., 1983, 20, N 6, 1601-1603

  摘要：

  DOI：

文献信息

• THIOXOTHIAZOLIDINE DERIVATIVE HAVING RAS FUNCTION INHIBITORY EFFECT
  申请人：Kataoka Tohru

  公开号：US20140194412A1

  公开（公告）日：2014-07-10

  The present invention provides an anticancer drug having a Ras function inhibitory action. The present invention provides a Ras function inhibitor comprising a compound represented by the formula (I′): wherein each symbol is as defined in the present specification, or a salt thereof.

  本发明提供一种具有Ras功能抑制作用的抗癌药物。 本发明提供一种包括由式(I′)表示的化合物的Ras功能抑制剂： 其中每个符号如本说明书中所定义，或其盐。
• [EN] ANTIBACTERIAL AGENTS : ARYLALKYLCARBOXAMIDO PHLOROGLUCINOLS<br/>[FR] AGENTS ANTIBACTÉRIENS : PHLOROGLUCINOLS ARYLALKYLCARBOXAMIDO
  申请人：UNIV RUTGERS

  公开号：WO2019173507A1

  公开（公告）日：2019-09-12

  The invention provides compounds of formula (I) or (II) and tautomers and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula (I) or (II) or a tautomer or salt thereof, methods of making a compound of formula (I) or (II) or a tautomer or salt thereof, and methods of using a compound of formula (I) or (II) or a tautomer or salt thereof as, e.g., inhibitors of bacterial RNA polymerase or as antibacterial agents.

  该发明提供了式（I）或（II）的化合物及其互变异构体和盐，其中变量如规范中所述，以及包含式（I）或（II）的化合物或其互变异构体或盐的组合物，制备式（I）或（II）的化合物或其互变异构体或盐的方法，以及使用式（I）或（II）的化合物或其互变异构体或盐的方法，例如，作为细菌RNA聚合酶的抑制剂或抗菌剂。
• N-sulphonylated amino acid derivatives, method for the production and use thereof
  申请人：Sturzebecher Jorg

  公开号：US20070055065A1

  公开（公告）日：2007-03-08

  The present invention relates to N-sulfonylated amino acid derivatives, where an aryl radical is linked via the sulfonyl group N-terminally to the amino acid and a radical which comprises at least one imino group and at least one further basic group which represents an optionally modified amino, amidino or guanidino group is linked C-terminally via the carbonyl group. The invention likewise relates to processes for preparing these compounds and to their use, in particular as inhibitors of matriptase.

  本发明涉及N-磺酰化氨基酸衍生物，其中芳基基团通过磺酰基N-末端与氨基酸连接，而包含至少一个亚胺基团和至少一个其他碱性基团的基团则通过羰基基团C-末端连接。本发明还涉及制备这些化合物的方法以及它们的用途，特别是作为matriptase的抑制剂。
• [EN] 3-ARYL-3-HYDROXY-2-METHYLENEPROPIONIC ACID ESTERS AS FUNGICIDES<br/>[FR] ESTERS D'ACIDE 3-ARYL-3-HYDROXY-2-METHYLENEPROPIONIQUE UTILISES EN TANT QUE FONGICIDES
  申请人：CROPSOLUTION INC

  公开号：WO2005115148A1

  公开（公告）日：2005-12-08

  Compounds of formula (I) are described: along with compositions thereof, methods of use thereof (particularly as fungicides), and methods of making the same.

  本文描述了化学式为(I)的化合物，以及其组合物、使用方法（尤其是作为杀真菌剂的方法）和制备方法。
• Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
  申请人：Zhu Yun-Fei

  公开号：US20070208049A1

  公开（公告）日：2007-09-06

  GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R 1 , R 2 , R 3a , R 3b , R 4 , R 5 , R 6 and n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

  本发明揭示了GnRH受体拮抗剂，其在治疗男女性激素相关疾病方面具有用途。本发明的化合物具有以下结构：其中A、Q、R1、R2、R3a、R3b、R4、R5、R6和n的定义如本文所述，包括立体异构体、前药和其药学上可接受的盐。本发明还揭示了含有本发明化合物与药学上可接受的载体组合的组合物，以及与其相关的方法，用于在需要时对抗促性腺激素释放激素。