2-Methyl-3-acetyl-4,5-dihydrofuran | 5831-64-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 2-Methyl-3-acetyl-4,5-dihydrofuran
• 英文别名: 3-acetyl-2-methyl-4,5-dihydrofuran；1-(2-Methyl-4,5-dihydrofuran-3-yl)ethan-1-one；1-(5-methyl-2,3-dihydrofuran-4-yl)ethanone
• CAS: 5831-64-1
• 化学式: C₇H₁₀O₂
• mdl: MFCD00464180
• 分子量: 126.155
• InChiKey: TYCSZMSASBKGMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Methyl-3-acetyl-4,5-dihydrofuran 以4%的产率得到
  参考文献：
  名称：

  ZEFIROV N. S.; KOZHUSHKOV S. I.; KUZNETSOVA T. S., XIMIYA GETEROTSIKL. SOEDIN., 1981, HO 9, 1285

  摘要：

  DOI：
• 作为产物：
  描述：

  1,1-乙酰基环丙烷 在 Wilkinson's catalyst 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以100%的产率得到2-Methyl-3-acetyl-4,5-dihydrofuran
  参考文献：
  名称：

  New conversions of substituted vinylcyclopropanes under the effect of complexes of rhodium and palladium

  摘要：

  Methods have been developed for the synthesis of the dimethyl ester of 1-carboxysorbic acid, 2-methyl-3-acetyl-5-vinyl- and 2-methyl-3-ethylcarboxy-5-vinyldihydrofurans by isomerization, respectively, of 1,1-dimethylcarboxy-2-vinyl-1, 1,1-diacetyl-2-vinyl-, and 1-acetyl-l-ethylcarboxy-2-vinylcyclo-propanes under the effect of Rh- and Pd-containing catalysts promoted with AcOH or CF3COOH.

  DOI：

  10.1007/bf00957856

文献信息

• Zefirov, N. S.; Kuznetsova, T. S.; Kozhushkov, S. I., Journal of Organic Chemistry USSR (English Translation), 1983, vol. 19, p. 474 - 480
  作者：Zefirov, N. S.、Kuznetsova, T. S.、Kozhushkov, S. I.、Surmina, L. S.、Rashchupkina, Z. A.

  DOI：——

  日期：——
• DZHEMILEV, U. M.;XUSNUTDINOV, R. I.;SHCHADNEVA, N. A.;TOLSTIKOV, G. A., IZV. AN CCCP. CEP. XIM.,(1990) N, S. 1598-1601
  作者：DZHEMILEV, U. M.、XUSNUTDINOV, R. I.、SHCHADNEVA, N. A.、TOLSTIKOV, G. A.

  DOI：——

  日期：——
• ZEFIROV, N. S.;KUZNETSOVA, T. S.;KOZHUSHKOV, S. I.;SURMINA, L. S.;RASHCHU+, ZH. ORGAN. XIMII, 1983, 19, N 3, 541-548
  作者：ZEFIROV, N. S.、KUZNETSOVA, T. S.、KOZHUSHKOV, S. I.、SURMINA, L. S.、RASHCHU+

  DOI：——

  日期：——
• Synthesis of 1-substituted 4-(2-hydroxyethyl)-3,5-dimethylpyrazoles
  作者：R. A. Karakhanov、M. M. Vartanyan、T. Yu. Solov'eva、V. A. Zefirova

  DOI：10.1007/bf00505865

  日期：1984.1
• New conversions of substituted vinylcyclopropanes under the effect of complexes of rhodium and palladium
  作者：U. M. Dzhemilev、R. I. Khusnutdinov、N. A. Shchadneva、G. A. Tolstikov

  DOI：10.1007/bf00957856

  日期：1990.7

  Methods have been developed for the synthesis of the dimethyl ester of 1-carboxysorbic acid, 2-methyl-3-acetyl-5-vinyl- and 2-methyl-3-ethylcarboxy-5-vinyldihydrofurans by isomerization, respectively, of 1,1-dimethylcarboxy-2-vinyl-1, 1,1-diacetyl-2-vinyl-, and 1-acetyl-l-ethylcarboxy-2-vinylcyclo-propanes under the effect of Rh- and Pd-containing catalysts promoted with AcOH or CF3COOH.