6-chloro-1-methyl-3-phenylpyridin-2(1H)-one | 67970-91-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-chloro-1-methyl-3-phenylpyridin-2(1H)-one
• 英文别名: 6-Chlor-1-methyl-3-phenyl-2(1H)-pyridon；6-chloro-1-methyl-3-phenyl-1H-pyridin-2-one；6-chloro-1-methyl-3-phenylpyridin-2-one
• CAS: 67970-91-6
• 化学式: C₁₂H₁₀ClNO
• 分子量: 219.671
• InChiKey: CPEIJVTZUDVLKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-chloro-1-methyl-3-phenylpyridin-2(1H)-one 、 甲醇 生成 6-Methoxy-1-methyl-3-phenyl-2(1H)-pyridon
  参考文献：
  名称：

  KUBO KAZUO; ITO NORIKI; ISOMURA YASUO; SOZU ISAO; ARIMA HIDEKI; HOMMA HIR+, YAKUGAKU DZASSI, YAKUGAKU ZASSNI, J. PHARM. SOS. JAR., 1979, 99, NO 6, 58+

  摘要：

  DOI：
• 作为产物：
  描述：

  6-Chlor-3-phenyl-2(1H)-pyridon 、 硫酸二甲酯 生成 6-chloro-1-methyl-3-phenylpyridin-2(1H)-one
  参考文献：
  名称：

  KUBO KAZUO; ITO NORIKI; ISOMURA YASUO; SOZU ISAO; ARIMA HIDEKI; HOMMA HIR+, YAKUGAKU DZASSI, YAKUGAKU ZASSNI, J. PHARM. SOS. JAR., 1979, 99, NO 6, 58+

  摘要：

  DOI：

文献信息

• Highly C3-Selective Direct Alkylation and Arylation of 2-Pyridones under Visible-Light-Promoted Photoredox Catalysis
  作者：Masahiro Miura、Koji Hirano、Atifah Najib、Sho Tabuchi

  DOI：10.3987/com-16-13459

  日期：——

  An Ir photoredox catalyst-mediated highly site-selective direct alkylation and arylation of 2-pyridones has been developed. Under visible-light-promoted conditions, ethyl 2-bromo-2,2-difluoroacetate couples with various 2-pyridones exclusively at the C3 position. A similar photoredox catalysis is also effective for the direct C3-arylation with diaryliodonium triflates. Thus, these reactions occurs under very mild conditions (blue LEDs irradiation and ambient temperature) to form the corresponding C3-alkylated and arylated 2-pyridones of potential interest in medicinal and pharmaceutical chemistry.