(R)-2-甲基哌嗪双盐酸盐 | 75336-89-9

• 物质功能分类: 医药中间体 - 杂环化合物 - 哌嗪类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: (R)-2-甲基哌嗪双盐酸盐
• 英文名称: (R)-2-Methylpiperazine dihydrochloride
• 英文别名: (2R)-2-methylpiperazine;dihydrochloride
• CAS: 75336-89-9
• 化学式: C5H14Cl2N2
• mdl: MFCD11053491
• 分子量: 173.08
• InChiKey: XMUWOBYBMGVFIU-ZJIMSODOSA-N

物化性质

• 熔点：
  259-261 °C (sublm)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.31
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  4
• 氢受体数：
  2

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  (R)-2-甲基哌嗪双盐酸盐 、 1-(2,4-二氟苯基)-6,7-二氟-1,4-二氢-4-氧代喹啉-3-羧酸 生成 Temafloxacin hydrochloride, (R)-
  参考文献：
  名称：

  CHU, DANIEL T. W.;NORDEEN, CARL W.;HARDY, DWIGHT J.;SWANSON, ROBERT N.;GI+, J. MED. CHEM., 34,(1991) N, C. 168-174

  摘要：

  DOI：
• 作为产物：
  描述：

  [(4S,5S,9R)-5-benzoyloxy-9-methyl-3,6-dioxo-2,7-dioxa-1,8-diazoniabicyclo[6.2.2]dodecan-4-yl] benzoate 、 氯仿 、 sodium hydroxide 以53%的产率得到
  参考文献：
  名称：

  ARMAREGO W. L. F.; SCHOU H.; WARING P., J. CHEM. RES. SYNOP., 1980, NO 4, 133, (M 1951-1966)

  摘要：

  DOI：

文献信息

• Novel tricyclic compound or salts thereof, method for producing the same and antimicrobial agent containing the same
  申请人：WAKUNAGA SEIYAKU KABUSHIKI KAISHA

  公开号：EP0470578A1

  公开（公告）日：1992-02-12

  A tricyclic compound represented by the general formula (1) and salts thereof. A method for producing the tricyclic compound and salts thereof, and an antimicrobial agent containing the tricyclic compound and salts thereof as an active ingredient are also disclosed.

  由通式（1）代表的三环化合物及其盐类。 此外，还公开了一种生产该三环化合物及其盐类的方法，以及一种含有该三环化合物及其盐类作为活性成分的抗菌剂。
• METHOD FOR PRODUCING OPTICALLY ACTIVE 2-METHYLPIPERAZINE
  申请人：Toray Fine Chemicals Co., Ltd.

  公开号：EP3178815A1

  公开（公告）日：2017-06-14

  The present invention provides a method for producing an optically active 2-methylpiperazine including: adding a solvent to a solution of the optically active 2-methylpiperazine to carry out solvent replacement, and then being crystallized to obtain crystals of the optically active 2-methylpiperazine. The method for producing an optically active 2-methylpiperazine according to the present invention allows the optically active 2-methylpiperazine to be purified during the crystallization process, and thus it is possible to obtain an optically active 2-methylpiperazine having a high quality.

  本发明提供了一种生产光学活性2-甲基哌嗪的方法，包括：向光学活性2-甲基哌嗪的溶液中加入溶剂，进行溶剂置换，然后进行结晶，得到光学活性2-甲基哌嗪的晶体。根据本发明生产光学活性 2-甲基哌嗪的方法，可以在结晶过程中对光学活性 2-甲基哌嗪进行提纯，因此可以获得高质量的光学活性 2-甲基哌嗪。
• CHU, DANIEL T. W.;NORDEEN, CARL W.;HARDY, DWIGHT J.;SWANSON, ROBERT N.;GI+, J. MED. CHEM., 34,(1991) N, C. 168-174
  作者：CHU, DANIEL T. W.、NORDEEN, CARL W.、HARDY, DWIGHT J.、SWANSON, ROBERT N.、GI+

  DOI：——

  日期：——
• METHOD OF PRODUCING OPTICALLY ACTIVE 2-METHYLPIPERAZINE
  申请人：Toray Fine Chemicals Co., Ltd.

  公开号：US20170226066A1

  公开（公告）日：2017-08-10

  A method of producing an optically active 2-methylpiperazine includes: adding a solvent to a solution of the optically active 2-methylpiperazine to carry out solvent replacement, and then being crystallized to obtain crystals of the optically active 2-methylpiperazine. The method allows the optically active 2-methylpiperazine to be purified during the crystallization process, and thus it is possible to obtain an optically active 2-methylpiperazine having a high quality.
• US5254685A
  申请人：——

  公开号：US5254685A

  公开（公告）日：1993-10-19