2,4-dinitrophenylhydrazine | 60451-65-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dinitrophenylhydrazine
• 英文别名: (2,4-Dinitrophenyl)diazene
• CAS: 60451-65-2
• 化学式: C₆H₄N₄O₄
• 分子量: 196.122
• InChiKey: PMTRUZLYMFAVQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  128
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,4-dinitrophenylhydrazine 、 (4S,9S,17R,22R)-9,17-diphenyl-3,10,13,16,23-pentaoxatetracyclo[23.3.1.04,9.017,22]nonacosa-1(28),25-diene-27,29-dione 在 硫酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 1.5h， 以25%的产率得到(4R,9R,17S,22S)-27-[(2,4-dinitrophenyl)diazenyl]-9,17-diphenyl-3,10,13,16,23-pentaoxatetracyclo[23.3.1.04,9.017,22]nonacosa-1(28),25(29),26-trien-29-ol
  参考文献：
  名称：

  Synthesis of azophenolic crown ethers of C s symmetry incorporating cis-1-phenylcyclohexane-1,2-diol residues as a steric barrier and diastereotopic face selectivity in complexation of amines by their diastereotopic faces

  摘要：

  Azophenolic crown ethers 1 and 2 of C-s symmetry incorporating cis-1-phenylcyclohexane-1,2-diol residues as a steric barrier have been prepared. Diastereotopic face selectivity in complexation with 2-methoxyethylamine, n-propylamine and ethanolamine was examined using temperature-dependent H-1 NMR spectroscopy. Both bind ethanolamine stereoselectively to one of their diaseereotopic faces; the prediction of which diastereoisomeric complexwas preferentially formed is made on the basis of a CPK molecular-model examination ofthe complexes.

  DOI：

  10.1039/p19950001429

文献信息

• Isoquinolinium N-arylimides and acetylenic dipolarophiles; cycloadducts and their rearrangements
  作者：Klaus Bast、Tony Durst、Helmut Huber、Rolf Huisgen、Klaus Lindner、David S Stephenson、Robert Temme

  DOI：10.1016/s0040-4020(98)00430-x

  日期：1998.7

  ones and does not require acid catalysis; in some cases the initial adduct escapes 1H NMR observation. The products 11–17, obtained with ethyl phenylpropiolate, provide beautiful NMR models for steric interaction of benzo ring E and the 12-phenyl group. On treatment with strong acid, the pentacyclic rearrangement products suffer fragmentation; e.g., 11 furnishes 4-(o-aminophenyl)-isoquinoline and methyl

  乙炔二甲基丙炔酸盐，和乙基苯基丙超越在dipolarophilic活动相应的烯属羧酸酯VS。异喹啉鎓N-芳基酰亚胺，一类甲亚胺亚胺。所述cycloadducts含有Ñ ß -vinylphenylhydrazine系统并进入一个Fischer吲哚合成，其停止所述吲哚中的一个步骤短。炔属双极性亲和剂的环加合物所涉及的[3.3]-σ重排同样快于烯属双极性亲和剂，并且不需要酸催化。在某些情况下，最初的加合物无法通过1 H NMR观察到。产品11–17用苯丙酸乙酯获得的，为苯并环E和12-苯基的空间相互作用提供了漂亮的NMR模型。用强酸处理时，五环重排产物会碎裂。例如，11在甲醇HCl中提供4-（邻氨基苯基）-异喹啉和苯甲酰乙酸甲酯。
• Colorimetric methods and reagents for the assay of calcium in a test sample
  申请人：Bayer Corporation

  公开号：EP0561160A1

  公开（公告）日：1993-09-22

  A chromogenic compound found to be especially selective in the determination of calcium in blood of the general formula (I): where: R ishydrogen or lower alkyl; X isCH₂, CH₂CH₂, CH=CH; O, S, SO₂, S-S, NR; W isCH, C-OH or N; M isp-nitrophenylazo, 2,4-dinitrophenylazo, 2,4, 6-trinitrophenylazo, p-nitrostyryl, p-benzoquinoneimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo; or isothiazolyl-5-azo; k is0 or 1; l is0 or 1; and n is0 or 1. A reagent composition and synthesis of chromogenic compounds of general formula (I) are also disclosed.

  在测定血液中钙含量时具有特别选择性的通式 (I) 致色化合物： 其中 R 是氢或低级烷基； X 是 CH₂、CH₂CH₂、CH=CH；O、S、SO₂、S-S、NR； W 是 CH、C-OH 或 N； M 是对硝基苯偶氮、2,4-二硝基苯偶氮、2,4,6-三硝基苯偶氮、对硝基苯基、对苯醌亚氨基、双（4-二甲氨基苯基）羟甲基、3-苯基异噻唑基-5-偶氮、噻唑基-5-偶氮或异噻唑基-5-偶氮； k 为 0 或 1 l 为 0 或 1；以及 n 为 0 或 1。 还公开了通式(I)的发色性化合物的试剂组合物和合成方法。
• MOLECULAR-WIRE TYPE FLUORESCENT CHIRAL SENSOR
  申请人：Japan Science and Technology Agency

  公开号：EP1724293A1

  公开（公告）日：2006-11-22

  The present invention provides a fluorescent molecular wire including a fluorescent polymer main chain to which an optically active substituent is linked so as to be a conjugatable form, the optically active substituent being represented by formula (I) below: where R1 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms; R2, R3, R4, R5, R6, R7, R8, and R9 represent independently a hydrogen atom, a linear alkyl group having 1 to 30 carbon atoms that may have a substituent, a branched alkyl group having 2 to 30 carbon atoms that may have a substituent, a cyclic alkyl group having 3 to 30 carbon atoms that may have a substituent, an aryl group having 6 to 30 carbon atoms that may have a substituent, or an aralkyl group having 7 to 30 carbon atoms that may have a substituent, and R3 and R7 may be bonded respectively to R4 and R8 to form an alkylene group having 2 to 60 carbon atoms that may have a substituent; and R10 and R11 represent independently a hydrogen atom or an alkyl group having 1 to 15 carbon atoms that may have a heteroatom, and R10 and R11 may be bonded to form an alkylene group having 2 to 30 carbon atoms that may have a heteroatom.

  本发明提供了一种荧光分子线，包括一条荧光聚合物主链，主链上连接了一个光学活性取代基，从而成为一种可共轭形式，光学活性取代基由下式（I）表示： 其中 R1 代表氢原子或具有 1 至 10 个碳原子的烷基；R2、R3、R4、R5、R6、R7、R8 和 R9 分别独立地代表氢原子、具有 1 至 30 个碳原子且可能具有取代基的直链烷基、具有 2 至 30 个碳原子且可能具有取代基的支链烷基、具有 3 至 30 个碳原子且可能具有取代基的环状烷基、R3 和 R7 可分别与 R4 和 R8 键合，形成具有 2 至 60 个碳原子且可具有取代基的亚烷基；和 R10 和 R11 独立地代表氢原子或具有 1 至 15 个碳原子且可带有一个杂原子的烷基，R10 和 R11 可键合形成具有 2 至 30 个碳原子且可带有一个杂原子的亚烷基。
• Preparation and temperature-dependent enantioselectivities of homochiral phenolic crown ethers having aryl chiral barriers: thermodynamic parameters for enantioselective complexation with chiral amines
  作者：Koichiro Naemura、Kazuyuki Nishioka、Kazuko Ogasahara、Yasushi Nishikawa、Keiji Hirose、Yoshito Tobe

  DOI：10.1016/s0957-4166(97)00638-1

  日期：1998.2

  Homochiral crown ether (S,S)-1 containing I-naphthyl groups as chiral barriers together with the phenol moiety was prepared by using (S)-3 as a chiral subunit which was resolved in enantiomerically pure form by lipase-catalyzed enantioselective acylation of (+/-)-3. Homochiral phenolic crown ether (S,S)-2, containing phenyl groups as chiral barriers, was also prepared from (S)-5 which was derived from (S)-mandelic acid. The association constants for their complexes with chiral amines in CHCl(3) were determined at various temperatures by the UV-visible spectroscopic method demonstrating that the crown ethers (S,S)-1 and (S,S)-2 displayed the large Delta(R-S)Delta G values of 6.2 and 6.4 kJ mol(-1), respectively, towards the amine 21 at 15 degrees C. Thermodynamic parameters for complex formation were also determined and a linear correlation between T Delta(R-S)Delta S and Delta(R-S)Delta H values was observed. (C) 1998 Elsevier Science Ltd. All rights reserved.
• A colorimetric method and reagent for the assay of lithium in a test sample
  申请人：Bayer Corporation

  公开号：EP0498196B1

  公开（公告）日：1996-05-08