2-hydroxy-5-methyl-1-phenylhexan-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-5-methyl-1-phenylhexan-3-one
• 英文别名: sattabacin；(±)-sattabacin
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: XPMYTBIJWHMOIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 反应 2.0h， 生成 2-hydroxy-5-methyl-1-phenylhexan-3-one
  参考文献：
  名称：

  二镍催化的亚乙烯基三组分环加成反应

  摘要：

  二镍催化剂促进两个醛当量和一个亚乙烯基的[2+2+1]-环加成。所得亚甲基二氧戊环产物可在酸性条件下一锅脱保护以显示α-羟基酮。该方法可以方便地获得不对称烷基取代的α-羟基酮，而使用交叉苯偶姻反应选择性合成这些酮具有挑战性。机理研究与醛最初迁移插入二镍桥接亚乙烯基中一致。插入第二个醛，然后进行 C-O 还原消除，得到环加合物。在稀释条件下，由于所提出的金属环中间体的竞争性β-氢化物消除而产生烯酮副产物。提出了与亚甲基二氧戊环和烯酮的浓度依赖性形成一致的DFT模型。

  DOI：

  10.1039/d2sc02696a

文献信息

• Compositions and Methods for Fermentation of Biomass
  申请人：Parekh Sarad

  公开号：US20100268000A1

  公开（公告）日：2010-10-21

  In one aspect, this invention relates to production of useful fermentation end-products from biomass through simultaneous hydrolysis and fermentation by a microorganism, such as Clostridium phytofermentans . The invention also relates to the development of a process for efficient pretreatment and conversion of lignocellulosic biomass to end-products with high conversion efficiency (yield). In another aspect, methods for producing a fermentation end-product by fermenting hexose (C6) and pentose (C5) sugars with a microorganism, such as Clostridium phytofermentans are disclosed herein.

  在一个方面，这项发明涉及通过微生物（如植物发酵槽菌）的同时水解和发酵，从生物质中生产有用的发酵终产物。该发明还涉及开发一种高效预处理和转化木质纤维素生物质为高转化效率（产率）的终产物的过程。在另一个方面，本文介绍了利用微生物（如植物发酵槽菌）发酵己糖（C6）和戊糖（C5）糖产生发酵终产物的方法。
• BIOFUEL PRODUCTION
  申请人：Yoshikuni Yasuo

  公开号：US20090139134A1

  公开（公告）日：2009-06-04

  Methods, enzymes, recombinant microorganism, and microbial systems are provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided. Commodity chemical enriched, refinery-produced petroleum products are also provided, as well as methods for producing the same.

  提供了用于将多糖转化为适当的单糖或寡糖的方法、酶、重组微生物和微生物系统，例如从生物质中提取的多糖。同时提供了将适当的单糖或寡糖转化为商品化学品，如生物燃料的方法。本文描述的方法生产的商品化学品也提供了。此外，还提供了商品化学品富集的、精炼生产的石油产品，以及生产这些产品的方法。
• METHODS AND COMPOSITIONS FOR PRODUCING CHEMICAL PRODUCTS FROM C. PHYTOFERMENTANS
  申请人：Schmalisch Matthias

  公开号：US20110183382A1

  公开（公告）日：2011-07-28

  This invention provides systems and methods for the production of compounds by C. phytofermentans. C. phytofermentans is genetically-engineered for hydrolysis and fermentation of carbonaceous biomass to synthesize compounds of commercial value.

  这项发明提供了通过C. phytofermentans生产化合物的系统和方法。C. phytofermentans被基因工程化，用于水解和发酵碳质生物质以合成具有商业价值的化合物。
• Synthesis of acyloin natural products by Mukaiyama hydration
  作者：Michael Ricca、Wei Zhang、Jiaqi Li、Thomas Fellowes、Jonathan M. White、Paul S. Donnelly、Mark A. Rizzacasa

  DOI：10.1039/d2ob00651k

  日期：——

  The acyloin natural products are a family of bioactive compounds isolated from fungi and myxobacteria. The total synthesis of 7 members of the acyloin family was achieved via a HWE reaction followed by Mukaiyama–Isayama hydration, using novel Co(II) and Co(III) Schiff base SALPN complexes as catalysts for the key enone hydration step. Furthermore, we have shown that a mild acyloin rearrangement is

  acyloin 天然产物是从真菌和粘细菌中分离出来的一类生物活性化合物。使用新型 Co( II ) 和 Co( III ) 席夫碱 SALPN 配合物作为关键烯酮水合步骤的催化剂，通过HWE 反应和 Mukaiyama-Isayama 水合实现了 acyloin 家族 7 个成员的全合成。此外，我们已经证明，在向山水合条件下，温和的 acyloin 重排是可能的，这对于这种方法的成功至关重要。
• Isolated alcohol dehydrogenase enzymes and uses thereof
  申请人：Bio Architecture Lab, Inc.

  公开号：EP2463374A2

  公开（公告）日：2012-06-13

  Bacterial polynucleotides and polypeptides are provided in which the polypeptides have a dehydrogenase activity, such as an alcohol dehydrogenase (ADH) activity, an uronate, a 4-deoxy-L-erythro-5-hexoseulose uronate (DEHU) ((4S,5S)-4,5 dihydroxy-2,6-dioxohexanoate) hydrogenase activity, a 2-keto-3-deoxy-D-gluconate dehydrogenase activity, a D-mannuronate hydrogenase activity, and/or a D-mannnonate dehydrogenase activity. Methods, enzymes, recombinant microorganism, and microbial systems are also provided for converting polysaccharides, such as those derived from biomass, into suitable monosaccharides or oligosaccharides, as well as for converting suitable monosaccharides or oligosaccharides into commodity chemicals, such as biofuels. Commodity chemicals produced by the methods described herein are also provided.

  提供了细菌多核苷酸和多肽，其中的多肽具有脱氢酶活性，如醇脱氢酶（ADH）活性、尿酸盐、4-脱氧-L-赤式-5-己糖尿酸盐（DEHU）（（4S、5S）-4,5-二羟基-2,6-二氧代己酸）氢化酶活性、2-酮基-3-脱氧-D-葡萄糖酸脱氢酶活性、D-甘露酸氢化酶活性和/或 D-甘露酸脱氢酶活性。还提供了将多糖（如来自生物质的多糖）转化为合适的单糖或低聚糖，以及将合适的单糖或低聚糖转化为商品化学品（如生物燃料）的方法、酶、重组微生物和微生物系统。还提供了通过本文所述方法生产的商品化学品。