1,4-bis[(3-formyl-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)oxy]butane | 737003-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 1,4-bis[(3-formyl-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)oxy]butane
• 英文别名: 5-[4-(3-Formyl-1-methylpyrrolo[3,2-b]pyridin-5-yl)oxybutoxy]-1-methylpyrrolo[3,2-b]pyridine-3-carbaldehyde
• CAS: 737003-40-6
• 化学式: C₂₂H₂₂N₄O₄
• 分子量: 406.441
• InChiKey: WBCOSXKHTOCEAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  88.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,4-bis[(3-formyl-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)oxy]butane 在 镍 吡啶 、 乙酸铵 、 sodium tetrahydroborate 、 氢气 、 silica gel 作用下， 以 甲醇 、 二氯甲烷 、 氯仿 、 异丙醇 为溶剂， 120.0 ℃ 、275.79 kPa 条件下， 反应 22.0h， 生成 N-(2-{5-[4-({3-[2-(acetylamino)ethyl]-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl}oxy)butoxy]-1-methyl-1H-pyrrolo[3,2-b]pyridin-3-yl}ethyl)acetamide
  参考文献：
  名称：

  Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT1 receptors over melatonin MT2 receptors

  摘要：

  Several 4-azaindole and 7-azaindole dimer analogues of melatonin with a bisalkoxyalkyl spacer between the position 5 of each heterocycle were synthetized. Our aim was to investigate the influence of the spacers length on the selectivity of such compounds for the MT1 receptors over the MT2 receptors. Our results suggest the distance between indole ring seems to be an important parameter in determining the potency of binding with melatonin receptor site. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.03.005
• 作为产物：
  描述：

  N,N-二甲基甲酰胺 、 1,4-bis[(1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)oxy]butane 在 三氯氧磷 作用下， 反应 2.5h， 以95%的产率得到1,4-bis[(3-formyl-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)oxy]butane
  参考文献：
  名称：

  Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT1 receptors over melatonin MT2 receptors

  摘要：

  Several 4-azaindole and 7-azaindole dimer analogues of melatonin with a bisalkoxyalkyl spacer between the position 5 of each heterocycle were synthetized. Our aim was to investigate the influence of the spacers length on the selectivity of such compounds for the MT1 receptors over the MT2 receptors. Our results suggest the distance between indole ring seems to be an important parameter in determining the potency of binding with melatonin receptor site. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.03.005

文献信息

• Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT1 receptors over melatonin MT2 receptors
  作者：Carlos Larraya、Jérôme Guillard、Pierre Renard、Valérie Audinot、Jean A Boutin、Philippe Delagrange、Caroline Bennejean、Marie-Claude Viaud-Massuard

  DOI：10.1016/j.ejmech.2004.03.005

  日期：2004.6

  Several 4-azaindole and 7-azaindole dimer analogues of melatonin with a bisalkoxyalkyl spacer between the position 5 of each heterocycle were synthetized. Our aim was to investigate the influence of the spacers length on the selectivity of such compounds for the MT1 receptors over the MT2 receptors. Our results suggest the distance between indole ring seems to be an important parameter in determining the potency of binding with melatonin receptor site. (C) 2004 Elsevier SAS. All rights reserved.