(5R,7R)-5,7-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3,2]dioxathiocane 2,2-dioxide | 191660-28-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: (5R,7R)-5,7-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3,2]dioxathiocane 2,2-dioxide
• 英文别名: tert-butyl-[[(5R,7R)-7-[[tert-butyl(diphenyl)silyl]oxymethyl]-2,2-dioxo-1,3,2-dioxathiocan-5-yl]methoxy]-diphenylsilane
• CAS: 191660-28-3
• 化学式: C₃₉H₅₀O₆SSi₂
• 分子量: 703.059
• InChiKey: TZAWVRBGDZCWMF-LQJZCPKCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.05
• 重原子数：
  48
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (5R,7R)-5,7-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3,2]dioxathiocane 2,2-dioxide 在 硫酸 、 三乙基硼氢化锂 作用下， 生成 (2S,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-pentan-1-ol
  参考文献：
  名称：

  Toward a total synthesis of an aglycone of spiramycine; two complementary accesses to a C-5C-9 fragment

  摘要：

  Both homochiral acetates 4d and 5f, which were obtained by lipase-catalysed acetylation of either the tetraol 4a or the diol 5e, respectively have been convened stereoconvergently into a C-5/C-9 fragment of the title antibiotic. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00945-3
• 作为产物：
  描述：

  (2S,4S)-2,4-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-pentane-1,5-diol 在 ruthenium trichloride 、 sodium periodate 、 磺酰氯 、 三乙胺 作用下， 以 四氯化碳 、 水 、 乙腈 为溶剂， 反应 51.0h， 生成 (5R,7R)-5,7-Bis-(tert-butyl-diphenyl-silanyloxymethyl)-[1,3,2]dioxathiocane 2,2-dioxide
  参考文献：
  名称：

  Toward a total synthesis of an aglycone of spiramycine; two complementary accesses to a C-5C-9 fragment

  摘要：

  Both homochiral acetates 4d and 5f, which were obtained by lipase-catalysed acetylation of either the tetraol 4a or the diol 5e, respectively have been convened stereoconvergently into a C-5/C-9 fragment of the title antibiotic. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00945-3

文献信息

• Toward a total synthesis of an aglycone of spiramycine; two complementary accesses to a C-5C-9 fragment
  作者：G Oddon、D Uguen

  DOI：10.1016/s0040-4039(97)00945-3

  日期：1997.6

  Both homochiral acetates 4d and 5f, which were obtained by lipase-catalysed acetylation of either the tetraol 4a or the diol 5e, respectively have been convened stereoconvergently into a C-5/C-9 fragment of the title antibiotic. (C) 1997 Published by Elsevier Science Ltd.