1-methyl-1-(2',4'-dibromophenyl)hydrazine | 89694-73-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methyl-1-(2',4'-dibromophenyl)hydrazine
• 英文别名: 1-(2,4-Dibromophenyl)-1-methylhydrazine
• CAS: 89694-73-5
• 化学式: C₇H₈Br₂N₂
• 分子量: 279.962
• InChiKey: PIAPIGSUODCCKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (2,4-二溴-苯基)-肼 、 碘甲烷 在 sodium amide 作用下， 生成 1-methyl-1-(2',4'-dibromophenyl)hydrazine
  参考文献：
  名称：

  Synthesis of tritiated N1′-alkyl derivatives of the delta opioid receptor ligand naltrindole

  摘要：

  Tritiated N1'-methyI and N1'-ethyl analogues of naltrindole (NTI) have been synthesized for evaluation as radioligands for studies of delta opioid receptors. The two N1'-alkyl-5',7'-dibromoNTI precursors for radiolabeling were prepared by base-promoted alkylation of 2,4-dibromophenylhydrazine with either iodomethane or iodoethane followed by condensation with naltrexone using the Fischer indole synthesis. Catalytic debromotritiation followed by HPLC purification afforded [H-3]MeNTI (17.3 Ci/mmol) and [H-3]EtNTI (22.5 Ci/mmol)with high chemical and radiochemical purities (greater than or equal to 99.8%).

  DOI：

  10.1002/(sici)1099-1344(199702)39:2<115::aid-jlcr947>3.0.co;2-3

文献信息

• Synthesis of tritiated N1′-alkyl derivatives of the delta opioid receptor ligand naltrindole
  作者：John R. Lever、Suzanne M. Johnson

  DOI：10.1002/(sici)1099-1344(199702)39:2<115::aid-jlcr947>3.0.co;2-3

  日期：1997.2

  Tritiated N1'-methyI and N1'-ethyl analogues of naltrindole (NTI) have been synthesized for evaluation as radioligands for studies of delta opioid receptors. The two N1'-alkyl-5',7'-dibromoNTI precursors for radiolabeling were prepared by base-promoted alkylation of 2,4-dibromophenylhydrazine with either iodomethane or iodoethane followed by condensation with naltrexone using the Fischer indole synthesis. Catalytic debromotritiation followed by HPLC purification afforded [H-3]MeNTI (17.3 Ci/mmol) and [H-3]EtNTI (22.5 Ci/mmol)with high chemical and radiochemical purities (greater than or equal to 99.8%).