N-(2-(Piperidin-1-yl)ethyl)-N-[3-(3-(trifluoromethyl)phenoxy)benzyl]acetamide | 656822-76-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-(Piperidin-1-yl)ethyl)-N-[3-(3-(trifluoromethyl)phenoxy)benzyl]acetamide
• 英文别名: N-(2-piperidin-1-ylethyl)-N-[3-(3-trifluoromethylphenoxy)benzyl]acetamide；N-(2-piperidin-1-ylethyl)-N-[[3-[3-(trifluoromethyl)phenoxy]phenyl]methyl]acetamide
• CAS: 656822-76-3
• 化学式: C₂₃H₂₇F₃N₂O₂
• 分子量: 420.475
• InChiKey: BWCGDZKQSJZOFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-(2-(Piperidin-1-yl)ethyl)-N-[3-(3-(trifluoromethyl)phenoxy)benzyl]amine 、 乙酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 N-(2-(Piperidin-1-yl)ethyl)-N-[3-(3-(trifluoromethyl)phenoxy)benzyl]acetamide
  参考文献：
  名称：

  [EN] AMINOALKYL-SUBSTITUTED ARYL COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS
  [FR] COMPOSES D'ARYLE SUBSTITUES PAR UN AMINOALKYLE ET LEUR UTILISATION EN TANT QU'ELEMENTS BLOQUANTS DU CANAL DE SODIUM

  摘要：

  本发明涉及使用新型氨基烷基取代芳基化合物(I)或其药学上可接受的盐或溶剂，其中n、X、R1、R2和R3在说明书中定义，用于治疗对钠离子通道阻滞有反应的疾病的方法。本发明还涉及使用式(I)化合物治疗全球或局部缺血后的神经损伤，治疗或预防神经退行性疾病，如肌萎缩性侧索硬化症（ALS），以及作为抗耳鸣剂，抗癫痫剂，抗躁狂抑郁剂，局部麻醉剂，抗心律失常药物和治疗或预防糖尿病性神经病变的方法。

  公开号：

  WO2004013114A1

文献信息

• Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers
  申请人：Euro-Celtique S.A.

  公开号：US20040116415A1

  公开（公告）日：2004-06-17

  This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aminoalkyl-substituted aryl compounds of Formula I: 1 or a pharmaceutically-acceptable salt or solvate thereof, wherein n, X, R 1 , R 2 and R 3 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of acute or chronic pain, neuropathic pain or surgical pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及使用式I中的新型氨基烷基取代芳基化合物或其药学上可接受的盐或溶剂的方法，其中n，X，R1，R2和R3在规范中定义，用于治疗对钠离子通道阻滞有反应的疾病。本发明还涉及使用式I的化合物治疗全球或局部缺血后的神经损伤，治疗或预防神经退行性疾病，如肌萎缩性侧索硬化（ALS），治疗、预防或改善急性或慢性疼痛，神经性疼痛或手术疼痛，作为抗耳鸣剂，抗癫痫药物和抗躁狂抑郁药物，局部麻醉剂，抗心律失常药物以及治疗或预防糖尿病神经病变。
• AMINOALKYL-SUBSTITUTED ARYL COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS
  申请人：Euro-Celtique S.A.

  公开号：EP1525194A1

  公开（公告）日：2005-04-27
• [EN] AMINOALKYL-SUBSTITUTED ARYL COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS<br/>[FR] COMPOSES D'ARYLE SUBSTITUES PAR UN AMINOALKYLE ET LEUR UTILISATION EN TANT QU'ELEMENTS BLOQUANTS DU CANAL DE SODIUM
  申请人：EURO CELTIQUE SA

  公开号：WO2004013114A1

  公开（公告）日：2004-02-12

  This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aminoalkyl-substituted aryl compounds of Formula (I), or a pharmaceutically-acceptable salt or solvate thereof, wherein n, X, Rl, R2 and R3 are defined in the specification. The invention is also directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of acute or chronic pain, neuropathic pain or surgical pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及使用新型氨基烷基取代芳基化合物(I)或其药学上可接受的盐或溶剂，其中n、X、R1、R2和R3在说明书中定义，用于治疗对钠离子通道阻滞有反应的疾病的方法。本发明还涉及使用式(I)化合物治疗全球或局部缺血后的神经损伤，治疗或预防神经退行性疾病，如肌萎缩性侧索硬化症（ALS），以及作为抗耳鸣剂，抗癫痫剂，抗躁狂抑郁剂，局部麻醉剂，抗心律失常药物和治疗或预防糖尿病性神经病变的方法。