2-氟-N-(2-甲基苄基)苯甲酰胺 | 915754-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氟-N-(2-甲基苄基)苯甲酰胺
• 英文名称: N-[3-(dimethylamino)propyl]-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide
• 英文别名: sFRP-1 Inhibitor；5-(benzenesulfonyl)-N-[3-(dimethylamino)propyl]-2-ethylbenzenesulfonamide
• CAS: 915754-88-0
• 化学式: C₁₉H₂₆N₂O₄S₂
• 分子量: 410.558
• InChiKey: BHFFSIFXFHJJNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  100
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-benzenesulfonyl-2-ethylbenzenesulfonyl chloride 、 N,N-二甲基-1,3-二氨基丙烷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以33 mg的产率得到2-氟-N-(2-甲基苄基)苯甲酰胺
  参考文献：
  名称：

  Identification of Diarylsulfone Sulfonamides as Secreted Frizzled Related Protein-1 (sFRP-1) Inhibitors

  摘要：

  Inhibitor of secreted frizzled related protein-1 (sFRP-1) would be a novel potential osteogenic agent, since loss of sFRP-1 affects osteoblast proliferation, differentiation, and activity, resulting in improved bone mineral density, quality, and strength. We have identified small molecule diarylsulfone sulfonamide derivatives as sFRP-1 inhibitors. Struture-activity relationship generated for various regions of the scaffold was utilized to improve the biochemical profile, resulting in the identification of potent selective analogues, such as 16 with desirable pharmaceutical profile.

  DOI：

  10.1021/jm801069w

文献信息

• [EN] METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION<br/>[FR] PROCÉDÉS POUR LA PROLIFÉRATION DES CELLULES SOUCHES DES FOLLICULES PILEUX
  申请人：FREQUENCY THERAPEUTICS INC

  公开号：WO2018191350A1

  公开（公告）日：2018-10-18

  The present invention relates to compositions of Sonic Hedgehog (Shh) pathway activators and Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.

  本发明涉及Sonic Hedgehog（Shh）通路激活剂和Wnt激动剂的组合物，以及使用它们诱导毛囊干细胞自我更新的方法，包括诱导毛囊干细胞增殖，同时保持子细胞具有分化为毛囊上皮细胞的能力。
• METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION
  申请人：Frequency Therapeutics, Inc.

  公开号：US20200121681A1

  公开（公告）日：2020-04-23

  The present invention relates to compositions of minoxidil and Sonic Hedgehog (Shh) pathway activators and optionally, Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.

  本发明涉及米诺地尔和Sonic Hedgehog (Shh)途径激活剂以及可选的Wnt激动剂的组合物，以及使用它们诱导毛囊干细胞的自我更新的方法，包括诱导毛囊干细胞增殖，同时保持子细胞具有分化为毛囊上皮细胞的能力。
• Diarylsulfone sulfonamides and use thereof
  申请人：Gopalsamy Ariamala

  公开号：US20060276464A1

  公开（公告）日：2006-12-07

  Compounds of Formula 1, or pharmaceutically acceptable salts thereof, are provided: which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis.

  提供公式1的化合物或其药用可接受盐：它们是分泌的毛细胞突变相关蛋白-1的调节剂。这些化合物和含有这些化合物的组合物可用于治疗多种疾病，包括骨质疏松症。
• Compositions and methods for generating hair cells by upregulating JAG-1
  申请人：Frequency Therapeutics, Inc.

  公开号：US11162071B2

  公开（公告）日：2021-11-02

  Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.

  本文提供了包含 Jag-1 激动剂的组合物和方法，用于增加耳蜗支持细胞或前庭支持细胞的增殖，以及治疗听力或平衡失调的相关方法。
• DIARYLSULFONE SULFONAMIDES AND USE THEROF
  申请人：Wyeth

  公开号：EP1879859A2

  公开（公告）日：2008-01-23