5-bromo-3-methyl-N-prop-2-ynylpyridin-2-amine | 1420041-98-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-bromo-3-methyl-N-prop-2-ynylpyridin-2-amine
• CAS: 1420041-98-0
• 化学式: C₉H₉BrN₂
• 分子量: 225.088
• InChiKey: PODRACPZRHPUAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-bromo-3-methyl-N-prop-2-ynylpyridin-2-amine 以 水 为溶剂， 生成 6-bromo-3,8-dimethylimidazo[1,2-a]pyridine
  参考文献：
  名称：

  [EN] ANTAGONIST OF ADENOSINE RECEPTORS
  [FR] ANTAGONISTE DES RÉCEPTEURS DE L'ADÉNOSINE

  摘要：

  The present invention relates to compounds of formula I shown below: wherein R1, R4, R5and R6are each as defined in the application. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or conditions in which adenosine A2a and/or A2b receptor activity is implicated, such as, for example, cancer.

  公开号：

  WO2023144559A1
• 作为产物：
  描述：

  tert-butyl N-(5-bromo-3-methyl-2-pyridyl)-N-prop-2-ynyl-carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 5-bromo-3-methyl-N-prop-2-ynylpyridin-2-amine
  参考文献：
  名称：

  [EN] ANTAGONIST OF ADENOSINE RECEPTORS
  [FR] ANTAGONISTE DES RÉCEPTEURS DE L'ADÉNOSINE

  摘要：

  The present invention relates to compounds of formula I shown below: wherein R1, R4, R5and R6are each as defined in the application. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or conditions in which adenosine A2a and/or A2b receptor activity is implicated, such as, for example, cancer.

  公开号：

  WO2023144559A1

文献信息

• Synthesis of Imidazo[1,2-<i>a</i>]pyridines: “Water-Mediated” Hydroamination and Silver-Catalyzed Aminooxygenation
  作者：Darapaneni Chandra Mohan、Sadu Nageswara Rao、Subbarayappa Adimurthy

  DOI：10.1021/jo3025303

  日期：2013.2.1

  Aqueous syntheses of methylimidazo[1,2-a]pyridines without any deliberate addition of catalyst are reported. Imidazo[1,2-a]pyrazine and imidazo[2,1-a]isoquinoline were also obtained in good yields under similar conditions. With acetonitrile as solvent, Ag-catalyzed intra-molecular aminooxygenation produced imidazo[1,2-a]pyridine-3-carbaldehydes in moderate to good yields.