4-trifluoromethoxy-3-(3,5,5,8,7-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-benzaldehyde | 500165-16-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-trifluoromethoxy-3-(3,5,5,8,7-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-benzaldehyde
• 英文别名: 4-Trifluoromethoxy-3-(3,5,5,8,7-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzaldehyde；3-(3,5,5,7,8-pentamethyl-7,8-dihydro-6H-naphthalen-2-yl)-4-(trifluoromethoxy)benzaldehyde
• CAS: 500165-16-2
• 化学式: C₂₃H₂₅F₃O₂
• 分子量: 390.446
• InChiKey: DYSXICHKBIXLOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-trifluoromethoxy-3-(3,5,5,8,7-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-benzaldehyde 、 硼氢化钠 、 甲醇 在 溶剂黄146 、 乙酸乙酯 、 碳酸氢钠 、 水 、 Brine 、 magnesium sulfate 、 silica gel 作用下， 反应 0.5h， 以to afford 0.400 g (22%) of 3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-4-trifluoromethoxy benzyl alcohol的产率得到3-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-4-trifluoromethoxy benzyl alcohol
  参考文献：
  名称：

  Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia

  摘要：

  本发明涉及式(I)的化合物，该化合物可用于治疗代谢性疾病、血脂异常和/或高胆固醇血症等疾病。

  公开号：

  US20030083357A1
• 作为产物：
  描述：

  3-溴-4-(三氟甲氧基)苯甲醛 、 3,5,5,8,8-五甲基-5,6,7,8-四氢萘-2-硼酸 、 乙醇 、 potassium carbonate 在 四(三苯基膦)钯 氩 、 水 、 Brine 、 magnesium sulfate 、 silica gel 作用下， 以 甲苯 、 乙酸乙酯 、 水 为溶剂， 反应 22.67h， 以to give 4-trifluoromethoxy-3-(3,5,5,8,7-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)benzaldehyde (11.1 g, 76%)的产率得到4-trifluoromethoxy-3-(3,5,5,8,7-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-benzaldehyde
  参考文献：
  名称：

  Thiazolidinedione derivatives for the treatment of diabetes and other diseases

  摘要：

  本发明涉及某些式(I)的取代杂环，其在治疗与脂质和碳水化合物代谢相关的疾病中有用，例如2型糖尿病、脂肪细胞分化、不受控制的增殖，如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或一般癌症；以及炎症，例如骨关节炎、类风湿性关节炎、克罗恩病或炎性肠病。

  公开号：

  US06765013B2

文献信息

• RXR activating molecules
  申请人：——

  公开号：US20030105333A1

  公开（公告）日：2003-06-05

  Disclosed are molecules that activate an RXR receptor, wherein the molecule comprises an RXR binding portion which binds the RXR receptor and comprises a side pocket contacting residue which contacts a side-pocket 1 of an RXR receptor.

  本发明涉及可以激活RXR受体的分子，其中所述分子包括与RXR受体结合的RXR结合部分，包括与RXR受体的侧袋1接触的侧袋接触残基。
• Substituted heterocycles for the treatment of diabetes and other diseases
  申请人：Pfahl Magnus

  公开号：US20060004059A1

  公开（公告）日：2006-01-05

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及公式（I）的某些取代杂环，其在治疗与脂质和碳水化合物代谢有关的疾病中有用，例如2型糖尿病，脂肪细胞分化，不受控制的增殖（如淋巴瘤，霍奇金病，白血病，乳腺癌，前列腺癌或癌症总体）和炎症（如骨关节炎，类风湿性关节炎，克罗恩病或炎性肠病）。
• Imidazolidinedione derivatives for the treatment of diabetes and other diseases
  申请人：Pfahl Magnus

  公开号：US20050070581A1

  公开（公告）日：2005-03-31

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及某些式(I)的取代杂环，其在治疗与脂质和碳水化合物代谢有关的疾病方面是有用的，例如2型糖尿病、脂肪细胞分化、不受控制的增殖，如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或普遍的癌症；以及炎症，例如骨关节炎、类风湿性关节炎、克罗恩病或炎性肠病。
• Heterocyclic derivatives for the treatment of diabetes and other diseases
  申请人：Maxia Pharmaceuticals, Inc.

  公开号：US06515003B1

  公开（公告）日：2003-02-04

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及一些配有取代基的杂环化合物（I）的使用，该化合物在治疗与脂质和碳水化合物代谢相关的疾病方面具有用途，例如2型糖尿病，脂肪细胞分化，无法控制的增殖，例如淋巴瘤，霍奇金病，白血病，乳腺癌，前列腺癌或普遍的癌症；以及炎症，例如骨关节炎，类风湿性关节炎，克罗恩病或炎性肠病。
• Benzylidene-thiazolidinediones and analogues and their use in the treatment of diabetes
  申请人：Incyte San Diego Incorporated

  公开号：EP1593677A2

  公开（公告）日：2005-11-09

  The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatiod arthritis, Crohn's Disease or Inflammatory Bowel Disease.

  本发明涉及某些取代的式(I)杂环，可用于治疗与脂质和碳水化合物代谢有关的疾病，如 2 型糖尿病、脂肪细胞分化、增殖失控，如淋巴瘤、霍奇金病、白血病、乳腺癌、前列腺癌或一般癌症；以及炎症，如骨关节炎、风湿性关节炎、克罗恩病或炎症性肠病。