(1R,2S,4S,5S,7R,8R,11R)-11-(hydroxymethyl)-7-methyl-4-{(1R)-1-methyl-2-[(triisopropylsilyl)oxy]ethyl}-5,7-bis[(triethylsilyl)oxy]-3,12-dioxatricyclo[6.3.1.0^2,4]dodecan-11-ol | 1006701-73-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: (1R,2S,4S,5S,7R,8R,11R)-11-(hydroxymethyl)-7-methyl-4-{(1R)-1-methyl-2-[(triisopropylsilyl)oxy]ethyl}-5,7-bis[(triethylsilyl)oxy]-3,12-dioxatricyclo[6.3.1.0^2,4]dodecan-11-ol
• 英文别名: (1R,2S,4S,5S,7R,8R,11R)-11-(hydroxymethyl)-7-methyl-5,7-bis(triethylsilyloxy)-4-[(2R)-1-tri(propan-2-yl)silyloxypropan-2-yl]-3,12-dioxatricyclo[6.3.1.02,4]dodecan-11-ol
• CAS: 1006701-73-0
• 化学式: C₃₆H₇₄O₇Si₃
• 分子量: 703.236
• InChiKey: YIFRBNWXEBQSIE-SOOMAIKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  46
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89.9
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (1R,2S,4S,5S,7R,8R,11R)-11-(hydroxymethyl)-7-methyl-4-{(1R)-1-methyl-2-[(triisopropylsilyl)oxy]ethyl}-5,7-bis[(triethylsilyl)oxy]-3,12-dioxatricyclo[6.3.1.0^2,4]dodecan-11-ol 在 2,2,6,6-tetramethyl-piperidine-N-oxyl 、 sodium hypochlorite 、 四丁基溴化铵 作用下， 以 二氯甲烷 、 碳酸氢钠 为溶剂， 反应 0.25h， 生成 (1R,2S,4S,5S,7R,8R,11S)-11-hydroxy-7-methyl-5,7-bis(triethylsilyloxy)-4-[(2R)-1-tri(propan-2-yl)silyloxypropan-2-yl]-3,12-dioxatricyclo[6.3.1.02,4]dodecane-11-carbaldehyde
  参考文献：
  名称：

  Stereoselective Construction of the Tricyclic Core of Neoliacinic Acid

  摘要：

  [GRAPHICS]The tricyclic core of the plant-derived sesquiterpene natural product neoliacinic acid was synthesized using a novel synthetic strategy. The pivotal synthetic transformations are construction of the key bicyclic ether-bridged intermediate by sequential deployment of metal carbenoid C-H insertion and ylide-forming reactions and installation of the lactone portion of neoliacinic acid by an acid-catalyzed intramolecular ring-opening reaction of an epoxide with a carboxylic acid.

  DOI：

  10.1021/jo702111u
• 作为产物：
  描述：

  (1R,2R,4S,5Z,7R,8R)-8-(hydroxymethyl)-2-methyl-5-{(1S)-1-methyl-2-[(triisopropylsilyl)oxy]ethyl}-2,4-bis[(triethylsilyl)oxy]-11-oxabicyclo[5.3.1]undec-5-en-8-ol 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以86%的产率得到(1R,2S,4S,5S,7R,8R,11R)-11-(hydroxymethyl)-7-methyl-4-{(1R)-1-methyl-2-[(triisopropylsilyl)oxy]ethyl}-5,7-bis[(triethylsilyl)oxy]-3,12-dioxatricyclo[6.3.1.0^2,4]dodecan-11-ol
  参考文献：
  名称：

  Stereoselective Construction of the Tricyclic Core of Neoliacinic Acid

  摘要：

  [GRAPHICS]The tricyclic core of the plant-derived sesquiterpene natural product neoliacinic acid was synthesized using a novel synthetic strategy. The pivotal synthetic transformations are construction of the key bicyclic ether-bridged intermediate by sequential deployment of metal carbenoid C-H insertion and ylide-forming reactions and installation of the lactone portion of neoliacinic acid by an acid-catalyzed intramolecular ring-opening reaction of an epoxide with a carboxylic acid.

  DOI：

  10.1021/jo702111u