4-bromo-6-ethyl-pyridine-2-carboxylic acid ethyl ester | 1242968-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-bromo-6-ethyl-pyridine-2-carboxylic acid ethyl ester
• 英文别名: ethyl 4-bromo-6-ethylpyridine-2-carboxylate
• CAS: 1242968-54-2
• 化学式: C₁₀H₁₂BrNO₂
• 分子量: 258.115
• InChiKey: LAIZQIGJJBQFAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-bromo-6-ethyl-pyridine-2-carboxylic acid ethyl ester 、 2-氨基-5-氟吡啶 生成 4-bromo-6-ethyl-pyridine-2-carboxylic acid (5-fluoro-pyridin-2-yl)-amide
  参考文献：
  名称：

  PYRIDINE-2-YL CARBOXYLIC ACID AMIDES

  摘要：

  本发明涉及作为代谢型谷氨酸受体拮抗剂的吡啶-2-基-羧酸酰胺。具体而言，本发明涉及式I中R1，R2，R3和R4如说明书所述的吡啶-2-基-羧酸酰胺。

  公开号：

  US20100227887A1

文献信息

• [EN] PYRIDINE-2-YL-CARBOXYLIC ACID AMIDES<br/>[FR] AMIDES D'ACIDES PYRIDINE-2-YL-CARBOXYLIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010100050A1

  公开（公告）日：2010-09-10

  The present invention relates to pyridine-2-yl-carboxylic acid amides which act as metabotropic glutamate receptor antagonists. In particular, the present invention relates to pyridine-2-yl-carboxylic acid amides of formula I wherein R1, R2, R3, and R4 are as described in the specification.
• [EN] NEW CHROMOPHORIC STRUCTURES FOR MACROCYCLIC LANTHANIDE CHELATES<br/>[FR] NOUVELLES STRUCTURES DE CHROMOPHORES POUR CHÉLATES DE LANTHANIDE MACROCYCLIQUES
  申请人：DHR FINLAND

  公开号：WO2016066641A1

  公开（公告）日：2016-05-06

  The present application discloses novel azamacrocyclic lanthanide chelate design (Formula (I)) having substituted 4-(phenylethynyl)pyridine chromophores around an emitting lanthanide core, e.g. an europium(III) ion. The chromophores exhibit high molar absorptivity and luminescence with lanthanide ions. The application also discloses a detectable molecule comprising a biospecific binding reagent conjugated to the luminescent chelate, luminescent lanthanide chelating ligand as well as a solid support conjugated with the chelates and their use in various assays.
• PYRIDINE-2-YL CARBOXYLIC ACID AMIDES
  申请人：Jaeschke Georg

  公开号：US20100227887A1

  公开（公告）日：2010-09-09

  The present invention relates to pyridine-2-yl-carboxylic acid amides which act as metabotropic glutamate receptor antagonists. In particular, the present invention relates to pyridine-2-yl-carboxylic acid amides of formula I wherein R 1 , R 2 , R 3 , and R 4 are as described in the specification.

  本发明涉及作为代谢型谷氨酸受体拮抗剂的吡啶-2-基-羧酸酰胺。具体来说，本发明涉及式I中的吡啶-2-基-羧酸酰胺，其中R1、R2、R3和R4如规范中描述的那样。