3,4-dimethoxybenzyl chloroformate | 35303-71-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dimethoxybenzyl chloroformate
• 英文别名: (3,4-Dimethoxyphenyl)methyl carbonochloridate
• CAS: 35303-71-0
• 化学式: C₁₀H₁₁ClO₄
• 分子量: 230.648
• InChiKey: NZLGPLMYXLCJRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,4-dimethoxybenzyl chloroformate 、 methyl 3-((benzylamino)methyl)benzoate 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3-{[benzyl-(3,4-dimethoxy-benzoyl)-amino]-methyl}-benzoic acid methyl ester
  参考文献：
  名称：

  WO2008/86047

  摘要：

  公开号：

文献信息

• Methods for the detection, analysis and isolation of nascent proteins
  申请人：AmberGen, Inc.

  公开号：US20040014071A1

  公开（公告）日：2004-01-22

  This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins containing these markers can be rapidly and efficiently detected, isolated and analyzed without the handling and disposal problems associated with radioactive reagents. Preferred markers are dipyrrometheneboron difluoride (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) dyes.

  本发明涉及一种非放射性标记物，可促进细胞或无细胞翻译系统中翻译出的新生蛋白质的检测和分析。含有这些标记物的新生蛋白质可以快速有效地检测、分离和分析，而不需要处理和处置放射性试剂所带来的问题。优选的标记物是二吡咯甲烷硼二氟化物（4,4-二氟-4-硼-3a,4a-二氮杂-茚）染料。
• Process for the preparation of pregnane derivatives
  申请人：——

  公开号：US20030181742A1

  公开（公告）日：2003-09-25

  A process for preparing pregnane derivatives represented by the formula (V), 1 which comprises the steps of: reacting an alkali (earth) metal with a compound represented by the formula (I) 2 in the presence of ammonia or an amine, to obtain a compound represented by the formula (II); 3 protecting the hydroxy groups of the obtained compound, to obtain a compound represented by the formula (III); 4 protecting the 3-position carbonyl group of the obtained compound, to obtain a compound represented by the formula (IV); 5 and subjecting the obtained compound to solvolysis; and the compound (II).

  一种制备以公式（V）表示的孕烷衍生物的方法，包括以下步骤：在氨或胺的存在下，将以公式（I）表示的化合物与碱金属（碱土金属）反应，得到以公式（II）表示的化合物；保护所得化合物的羟基，得到以公式（III）表示的化合物；保护所得化合物的3位置羰基基团，得到以公式（IV）表示的化合物；将所得化合物进行溶剂解离反应；以及化合物（II）。
• RHO KINASE INHIBITORS
  申请人：Dahmann Georg

  公开号：US20100041645A1

  公开（公告）日：2010-02-18

  Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile dysfunction and glaucoma.

  本文介绍了一种替代酰胺和脲衍生物，这些衍生物可用作Rho激酶的抑制剂，在治疗心血管疾病、癌症、神经系统疾病、肾脏疾病、支气管哮喘、勃起功能障碍和青光眼等各种疾病中有用。
• PROCESS FOR THE PREPARATION OF PREGNANE DERIVATIVES
  申请人：Kuraray Co., Ltd.

  公开号：EP1325928A1

  公开（公告）日：2003-07-09

  A process for preparing pregnane derivatives represented by the formula (V), which comprises the steps of: reacting an alkali (earth) metal with a compound represented by the formula (I) in the presence of ammonia or an amine, to obtain a compound represented by the formula (II); protecting the hydroxy groups of the obtained compound, to obtain a compound represented by the formula (III); protecting the 3-position carbonyl group of the obtained compound, to obtain a compound represented by the formula (IV); and subjecting the obtained compound to solvolysis; and the compound (II).

  一种制备式（V）所代表的孕烷衍生物的工艺、 该工艺包括以下步骤 碱（土）金属与式 (I) 所代表的化合物反应 在氨或胺存在下，使碱（土）金属与式 (I) 所代表的化合物反应，得到式 (II) 所代表的化合物； 保护所得化合物的羟基，得到式（III）代表的化合物； 保护所得化合物的 3 位羰基，得到式（IV）代表的化合物； 将得到的化合物进行溶解；得到化合物 (II)。
• N-terminal and C-terminal markers in nascent proteins
  申请人：AmberGen, Inc.

  公开号：US20020132248A1

  公开（公告）日：2002-09-19

  This invention relates to non-radioactive markers that facilitate the detection and analysis of nascent proteins translated within cellular or cell-free translation systems. Nascent proteins containing these markers can be rapidly and efficiently detected, isolated and analyzed without the handling and disposal problems associated with radioactive reagents. Methods are described for incorporating N-terminal, C-terminal and (optionally) affinity markers into a nascent protein

  本发明涉及有助于检测和分析在细胞或无细胞翻译系统中翻译的新生蛋白质的非放射性标记物。含有这些标记物的新生蛋白质可被快速有效地检测、分离和分析，而不存在与放射性试剂相关的处理和处置问题。本文介绍了将 N-端、C-端和（可选）亲和性标记物结合到新生蛋白质中的方法