H2-29 | 1228044-66-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: H2-29
• 英文别名: 3-(5-((3-(4-methoxyphenyl)-2-(4-methoxyphenylimino)-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)benzoic acid；3-[5-[[3-(4-methoxyphenyl)-2-(4-methoxyphenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzoic acid
• CAS: 1228044-66-3
• 化学式: C₂₉H₂₂N₂O₆S
• 分子量: 526.569
• InChiKey: BXIAQZWEFKESLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  127
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  methyl 3-[5-[[3-(4-methoxyphenyl)-2-(4-methoxyphenyl)imino-4-oxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]benzoate 在 甲醇 、 水 、 potassium carbonate 作用下， 反应 10.0h， 生成 H2-29
  参考文献：
  名称：

  Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

  摘要：

  A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 mu M. The structure-activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.013

文献信息

• ORGANIC ELECTROLUMINESCENT COMPOUND, A PLURALITY OF HOST MATERIALS, AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME
  申请人：ROHM AND HAAS ELECTRONIC MATERIALS KOREA LTD.

  公开号：US20220263031A1

  公开（公告）日：2022-08-18

  The present disclosure relates to an organic electroluminescent compound, a plurality of host materials, and an organic electroluminescent device comprising the same. By comprising an organic electroluminescent compound and/or a plurality of host materials according to the present disclosure, an organic electroluminescent device having low driving voltage and/or high luminous efficiency and/or long lifespan can be provided.

  本公开涉及一种有机电致发光化合物、多种宿主材料和包括它们的有机电致发光器件。通过根据本公开的有机电致发光化合物和/或多种宿主材料组成有机电致发光器件，可以提供具有低驱动电压和/或高发光效率和/或长寿命的有机电致发光器件。
• Thiazolidione derivatives as novel antibiofilm agents: Design, synthesis, biological evaluation, and structure–activity relationships
  作者：Bin Pan、Renzheng Huang、Likang Zheng、Chen Chen、Shiqing Han、Di Qu、Mingli Zhu、Ping Wei

  DOI：10.1016/j.ejmech.2010.12.014

  日期：2011.3

  Rational designed novel thiazolidiones were synthesized and evaluated for antibiofilm activity. The active derivatives were not only potent inhibitors of Staphylococcus epidermidis biofilm growth but also efficient antibacterial agents. 3f showed 4-fold higher activity (6.25 mu M) in the biofilms dispersal assay and significantly higher antibacterial activity (MIC 3.125 mu M) in comparison to the 3-(5-((6- (ethoxycarbonyl)-5-(benzo[1,3]dioxol-5-yl)-3-oxo-7-phenyl- thiazolo[3,2-a]pyrimidin-2(5H)-ylidene)methyl) furan-2-yl)benzoic acid (1). (C) 2010 Elsevier Masson SAS. All rights reserved.