2-(2-hydroxyethyl)pyridinium chloride | 101948-60-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2-hydroxyethyl)pyridinium chloride
• 英文别名: 2-ethanolpyridine hydrochloride；2-(Pyridin-2-yl)ethanol hydrochloride；2-pyridin-2-ylethanol;hydrochloride
• CAS: 101948-60-1
• 化学式: C₇H₉NO*ClH
• 分子量: 159.615
• InChiKey: LYFVKJPPHXWXSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.04
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  33.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tetraaquabis(saccharinato)cobalt(II) dihydrate 、 2-(2-hydroxyethyl)pyridinium chloride 以 甲醇 、 水 为溶剂， 以63%的产率得到bis(2-ethanolpyridinium) tetrachlorocobaltate(II)
  参考文献：
  名称：

  Cobalt(II) complexes of 2-methanol-, 2,6-dimethanol- and 2-ethanolpyridines: syntheses, spectroscopic, thermal and structural characterizations of [Co2(μ-Cl)2(mpy)4]Cl2·2H2O, [Co(dmpy)2]Cl2 and [Co(Cl)4](Hpyet)2 (mpy=2-methanolpyridine; dmpy=2,6-dimethanolpyridine and Hpyet=2-ethanolpyridinium)

  摘要：

  Cobalt(II) complexes of 2-methanol-, 2,6-dimethanol- and 2-ethanolpyridines have been prepared by the reaction of the corresponding protonated substituted pyridines with [Co(sac)(2)(H2O)(4)](.)2H(2)O, where sac is saccharinate, and characterised by elemental analyses, IR, UV-Vis, magnetic measurements and single crystal X-ray diffraction. The corresponding 2-methanolpyridine (mpy) complex [Co-2(mu-Cl)(2)(mpy)(4)]Cl(2)(.)2H(2)O is dimeric with chloro bridges and each cobalt(II) ion has an octahedral coordination with two chloro and two bidentate (N, O) ligands. In the 2,6-dimethanolpyridine (dmpy) complex [Co(dmpy)(2)]Cl-2, dmpy exhibits a tripodal chelating coordination mode through the N and two hydroxyl O atoms forming a CoN2O4 chromophore. The protonated 2-ethanolpyridinium cation Hpyet serves as a non-coordinating, but hydrogen bonded counter ion in [Co(Cl)(4)](Hpyet)(2). Based on the molecular structures, the electronic, IR spectra and thermal behavior of the complexes are discussed. 16 (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2003.12.007

文献信息

• Composition and device structure for iontophoresis
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1080731A2

  公开（公告）日：2001-03-07

  Device structure 100 for iontophoresis provides electrode 101 and electrically conductive layer 102. Electrically conductive layer 102 contains active ingredient D and basic water swelling methacrylate copolymer P1 and/or acidic water swelling methacrylate copolymer P2. Electrode 101 and electrically conductive layer 102 are placed into a hollow of backing 103 and electrode terminal 104 is connected to electrode 101 through backing 103. Adhesive layer 105 is set around backing 103, and liner 106 to be removed when using the device, is placed so as to cover the hollow of backing 103.

  用于离子透入的设备结构 100 包括电极 101 和导电层 102。导电层 102 含有活性成分 D 和碱性遇水膨胀甲基丙烯酸酯共聚物 P1 和/或酸性遇水膨胀甲基丙烯酸酯共聚物 P2。电极 101 和导电层 102 放入背衬 103 的中空部分，电极端子 104 通过背衬 103 与电极 101 连接。粘合剂层 105 镶在背衬 103 周围，衬垫 106 在使用设备时取下，以覆盖背衬 103 的中空部分。
• IONTOPHORESIS DEVICE
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1177813A1

  公开（公告）日：2002-02-06

  The present invention provides an iontophoresis device allowing effective and continuous absorption for a long period. The iontophoresis device comprises the first electrode structure (100a) and the second electrode structure (110a) each having a hydrophilic conductive layer (102a, 112a) containing active ingredient and an electrode member (101a, 111a), and a power supply (120a) having polarity inverting means for switching over a current direction between the two electrode structures, wherein at least one of the first and the second electrode structures contains chloride ions and before administration, a chloride-ion content (P mg) is within a range satisfying the following equation:1.0 × (I × T × 0.022) ≤ P    wherein T represents a polarity inverting time (min) until polarity is inverted after energization in a certain direction and I represents an average current (mA).

  本发明提供了一种可长期有效持续吸收的离子透入装置。该离子透入装置包括第一电极结构（100a）和第二电极结构（110a），每个电极结构都有一个含有活性成分的亲水性导电层（102a，112a）和一个电极部件（101a，111a），以及一个电源（120a），该电源具有极性反转装置，用于在两个电极结构之间切换电流方向，其中第一和第二电极结构中至少有一个含有氯离子，在给药前，氯离子含量（P mg）在满足下式的范围内：1.0 × (I × T × 0.022) ≤ P 其中，T 表示极性反转时间（分钟），直到按一定方向通电后极性反转为止，I 表示平均电流（毫安）。
• Symptomatic relief of gastrointestinal disorders
  申请人：——

  公开号：US20030175360A1

  公开（公告）日：2003-09-18

  A formulation for treating a gastrointestinal disorder is provided. The formulation provides symptomatic relief of symptoms associated with gastrointestinal disorders. Additionally, a method for treating a gastrointestinal disorder comprising administering a therapeutically effective amount of the formulation is provided.

  本文提供了一种用于治疗胃肠功能紊乱的制剂。该制剂可缓解与胃肠功能紊乱有关的症状。此外，还提供了一种治疗胃肠道疾病的方法，包括施用治疗有效量的制剂。
• PROCESSES FOR PREPARING 2-PIPERIDINEETHANOL COMPOUNDS
  申请人：REILLY INDUSTRIES, INC.

  公开号：EP1131289B1

  公开（公告）日：2006-02-08
• EP1131289A4
  申请人：——

  公开号：EP1131289A4

  公开（公告）日：2003-06-04