2,4-Dimethylcinnamaldehyde | 859930-33-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醛
• 英文名称: 2,4-Dimethylcinnamaldehyde
• 英文别名: 3-(2,4-dimethylphenyl)prop-2-enal
• CAS: 859930-33-9
• 化学式: C₁₁H₁₂O
• 分子量: 160.216
• InChiKey: FNVRKBJDPCPUQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4-Dimethylcinnamaldehyde 、 5,5-二甲基-1,3-环己二酮 在 (2S)-2-[二苯基[(三甲基硅酯)氧基]甲基]-吡咯烷 作用下， 以 二氯甲烷 为溶剂， 生成 (4R)-4-(2,4-dimethylphenyl)-2-hydroxy-7,7-dimethyl-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one 、 (4S)-4-(2,4-dimethylphenyl)-2-hydroxy-7,7-dimethyl-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one
  参考文献：
  名称：

  不对称有机催化：对苯并吡喃和苯并二甲基苯的有效对映选择性。

  摘要：

  DOI：

  10.1002/chem.200800836

文献信息

• [EN] NOVEL SPIROINDOLINE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS DE SPIROINDOLINE
  申请人：INTERVET INT BV

  公开号：WO2013017678A1

  公开（公告）日：2013-02-07

  This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及一种新型螺环吲哚烷化合物，通式为(I)，通常用作药物，更具体地用作动物药物。该药物可用于治疗蠕虫感染和寄生虫病的治疗，比如由蠕虫感染引起的寄生虫病。本发明还涉及利用这些化合物制备药物和治疗方案，包括将这些化合物用于需要治疗的动物。此外，本发明还涉及所述化合物的制备。此外，本发明还涉及包含这些化合物的药物组合物和工具包。
• Novel hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers
  申请人：Schwartz David A.

  公开号：US20080221343A1

  公开（公告）日：2008-09-11

  Conjugationally extended hydrazine compositions of the formula (RR 2 )N(H) n (NH 2 ) n , fluorescent hydrazone compositions of the formula (RR 2 )NN═C(R 1 R 2 ), methods of the formation of hydrazones from the reaction of conjugationally extended hydrazines with conjugationally extended carbonyls and methods of their use in assays systems are described. Use of these conjugationally extended hydrazine and oxime compositions for direct calorimetric and fluorometric assays wherein a chromophore or the fluorophore is incorporated into the linker that is positioned between a reactive linking moiety and a biotin molecule. More specifically the linker comprises one molecule of a high affinity binding pair such as for example biotin of the biotin/avidin high affinity binding pair, connected to a spacer molecule such as for example a length of polyethyleneglycol followed by a pro-chromophoric, chromophoric, pro-fluorescent or fluorescent moiety connected to an amino-, thiol- or carbohydrate-reactive moiety such as for example succinimidyl, maleimido or aminoxy group respectively, that may covalently link to a biomolecule.

  描述了公式(RR2)N(H)n(NH2)n的共轭扩展肼组合物，公式(RR2)NN═C(R1R2)的荧光肼酮组合物，以及从共轭扩展肼与共轭扩展羰基化合物反应形成肼酮的方法，以及在测定系统中使用它们的方法。利用这些共轭扩展肼和肟组合物进行直接量热和荧光测定，其中色团或荧光团被并入连接基团中，该连接基团位于反应性连接基团和生物素分子之间。更具体地，连接基团包括一分子高亲和性结合对之一，例如生物素/亲和素高亲和性结合对之一，连接到一个间隔分子，例如一段聚乙二醇长度，后接一个前色团、色团、前荧光团或荧光团，连接到一个氨基、硫醇或碳水化合物反应性基团，例如琥珀酰亚胺基、马来酰亚胺基或氨氧基团，可以共价连接到生物分子。
• [EN] FLUORESCENT PROBES<br/>[FR] SONDES FLUORESCENTES
  申请人：UNIV MASSACHUSETTS

  公开号：WO2018151949A1

  公开（公告）日：2018-08-23

  The present disclosure relates to compounds of Formula I, II, or III and compositions of the same, which are reversible off-on or ratiometric fluorescent iron sensors and are useful in live-cell imaging of labile iron ions and their quantification in subcellular compartments, as well as treatment of diseases associated with iron dyshomoestasis.

  本公开涉及公式I、II或III的化合物以及相同化合物的组合物，这些化合物是可逆的开关型或比色荧光铁传感器，可用于活细胞成像中的活性铁离子和其在亚细胞区域中的定量，以及与铁离子失衡相关疾病的治疗。
• NOVEL SPIROINDOLINE COMPOUNDS
  申请人：Chassaing Christophe Pierre Alain

  公开号：US20140163056A1

  公开（公告）日：2014-06-12

  This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及一种新的螺环吲哚类化合物，其化学式为(I)，通常作为药物使用，更具体地作为动物药物使用。该药物可以优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。本发明还涉及利用该化合物制备药物和治疗方法，包括将该化合物用于需要治疗的动物的治疗。本发明还涉及所述化合物的制备方法。此外，本发明还涉及包含该化合物的药物组合物和配套工具。
• Antibiotic intermediates
  申请人：ELI LILLY AND COMPANY

  公开号：EP0254578A1

  公开（公告）日：1988-01-27

  2,5-Disubstituted oxazolidin-4-one-3-ylacetyl chlorides and 1,2,5-substituted imidazolidin-4-one-3-yl-­acetyl chlorides function as chiral auxiliary moieties in the asymmetric cycloaddition with aldimines to pro­vide cis-azetidinones. The azetidinones are useful intermediates in the preparation of antibiotics.

  2,5-二取代的噁唑烷-4-酮-3-基乙酰氯和 1,2,5-取代的咪唑烷-4-酮-3-基乙酰氯在与醛亚胺的不对称环化反应中作为手性辅助分子提供顺式氮杂环丁酮。氮杂环丁酮是制备抗生素的有用中间体。