Potassium; 4-(triphenyl-λ⁵-phosphanylidene)-butyrate | 113428-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Potassium; 4-(triphenyl-λ⁵-phosphanylidene)-butyrate
• 英文别名: Potassium;4-(triphenyl-lambda5-phosphanylidene)butanoate；potassium;4-(triphenyl-λ5-phosphanylidene)butanoate
• CAS: 113428-25-4
• 化学式: C₂₂H₂₀O₂P*K
• 分子量: 386.472
• InChiKey: JVKGEWWXCNRVNX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.68
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1R,2S,3aR,7aR)-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-6-[dimethyl(phenyl)silyl]-2-(oxan-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-indene-5-carbaldehyde 、 Potassium; 4-(triphenyl-λ⁵-phosphanylidene)-butyrate 生成 methyl (E)-5-[(1R,2S,3aR,7aR)-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-6-[dimethyl(phenyl)silyl]-2-(oxan-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]pent-4-enoate
  参考文献：
  名称：

  TAKAHASHI, ATSUO;SHIBASAKI, MASAKATSU, TETRAHEDRON LETT., 28,(1987) N 17, 1893-1896

  摘要：

  DOI：

文献信息

• 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
  申请人：DeLong Mitchell Anthony

  公开号：US06894175B1

  公开（公告）日：2005-05-17

  2-Decarboxy-2-phosphinico prostaglandin derivatives are disclosed. These derivatives comprise a modified α-chain and an Ω-chain bonded to a ring structure. The modified α-chain has a 2-decarboxy-2-phosphinico group. The derivatives can be used to treat a variety of pharmaceutical and cosmetic conditions.

  本文披露了2-脱羧-2-膦基前列腺素衍生物。这些衍生物包括一个改性的α链和一个与环结构相结合的Ω链。改性的α链具有2-脱羧-2-膦基基团。这些衍生物可用于治疗各种药物和化妆品状况。
• Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 1. (.+-.)-(3-Pyridinylbicycloheptyl)alkanoic acids
  作者：Shripad S. Bhagwat、Candido Gude、David S. Cohen、Warren Lee、Patricia Furness、Frank H. Clarke

  DOI：10.1021/jm00110a006

  日期：1991.6

  The design, synthesis, and in vitro pharmacology of a new class of compounds exerting both thromboxane receptor antagonist and thromboxane synthase inhibitory activities is described. [(3-Pyridinyl)bicycloheptyl]alkanoic acid 9 and its analogues, designed with the help of molecular modeling, were synthesized and found to be inhibitors of thromboxane A2 (TxA2) biosynthesis in a human platelet microsomal preparation. The compounds were also found to antagonize both platelet and vascular TxA2 receptors. The compounds inhibited the U 46619 induced aggregation of human washed platelets and platelet-rich plasma and the U 46619 induced contraction of the dog saphenous vein.