1-ethyl-3-phenyl-imidazolidine-2,4-dione | 117541-81-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-ethyl-3-phenyl-imidazolidine-2,4-dione
• 英文别名: 1-Aethyl-3-phenyl-imidazolidin-2,4-dion；Phenyl-athyl-hydantoin；1-ethyl-3-phenylimidazolidine-2,4-dione
• CAS: 117541-81-8
• 化学式: C₁₁H₁₂N₂O₂
• 分子量: 204.228
• InChiKey: UTZPMJKUOIFUMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-乙甘胺酸 生成 1-ethyl-3-phenyl-imidazolidine-2,4-dione
  参考文献：
  名称：

  354.制备较简单的α-烷基氨基酸。第一部分

  摘要：

  DOI：

  10.1039/jr9370001693

文献信息

• [EN] SUBSTITUTED QUINOLINES AND THEIR USE AS MEDICAMENTS<br/>[FR] QUINOLÉINES SUBSTITUÉES ET LEUR UTILISATION COMME MÉDICAMENTS
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2013014060A1

  公开（公告）日：2013-01-31

  The invention relates to new substituted quinolines of formula (1) wherein R1 is a linear or branched C1-6-alkyl, wherein R1 may optionally be substituted by R3 which is selected from the group consisting of a three-, four-, five-, six- or seven-membered cycloalkl; a five-, six- or seven-membered, saturated heterocycle comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; and a five- or six-membered heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; wherein R3 may optionally be substituted further substituted as defined in claim 1 and wherein R2 is selected from the group consisting of halogen, phenyl, a five- or six-membered monocyclic heteroaryl comprising one, two or three heteroatoms each independently selected from the group consisting of N, S and O; a bicyclic, nine-, ten- or eleven-membered, either aromatic or non-aromatic, but not fully saturated heterocycle comprising one, two, three or four heteroatoms each independently selected from the group consisting of N, S and O; wherein R2 may optionally be further substituted as defined in claim 1, and their use in the preparation of medicaments for the treatment of disease such as asthma, COPD, allergic rhinitis, allergic dermatitis and rheumatoid arthritis.

  该发明涉及公式（1）中的新取代喹啉，其中R1是直链或支链的C1-6-烷基，其中R1可以选择性地被R3取代，R3选自以下组：三、四、五、六或七元环烷基；含有一个、两个或三个异原子（分别独立地选自N、S和O）的五、六或七元饱和杂环；含有一个、两个或三个异原子（分别独立地选自N、S和O）的五元或六元杂芳基；其中R3可以选择性地进一步取代，如权利要求书中所定义，R2选自以下组：卤素、苯基、含有一个、两个或三个异原子（分别独立地选自N、S和O）的五元或六元单环杂芳基；含有一个、两个、三或四个异原子（分别独立地选自N、S和O）的九、十或十一元双环芳香或非芳香但不完全饱和杂环；其中R2可以选择性地进一步取代，如权利要求书中所定义，并且它们在制备用于治疗哮喘、慢性阻塞性肺病、过敏性鼻炎、过敏性皮炎和类风湿性关节炎等疾病的药物中的用途。
• Method for measurement of trace enzymes
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0048834A1

  公开（公告）日：1982-04-07

  The amount of enzyme is determined by reacting an enzyme to be measured with a synthetic substrate having at least one structure to be specifically contacted with the enzyme and at least one spectral sensitizer structure, bringing either the reaction product having the spectral sensitizer structure or the unreacted synthetic substrate into contact with a silver halide emulsion layer, exposing the same to light of a spectral sensitizing wavelength region corresponding to the spectral sensitizer structure, developing the silver halide, and then measuring the optical density of developed silver and/or colored dye.

  酶量的测定方法是：将待测酶与具有至少一种与酶特异性接触的结构和至少一种光谱增感剂结构的合成底物反应，使具有光谱增感剂结构的反应产物或未反应的合成底物与卤化银乳剂层接触，将其暴露于与光谱增感剂结构相对应的光谱增感波长区域的光下，显影卤化银，然后测量显影银和/或有色染料的光密度。
• Silver halide light sensitive emulsion layer having enhanced photographic sensitivity
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0786692A1

  公开（公告）日：1997-07-30

  A photographic element comprises at least one silver halide emulsion layer in which the silver halide is sensitized with a compound of formula         Z-(L-XY)k wherein: Z is a light absorbing group; L is a linking group containing a least one C, N, S, or O atom; and k is 1 or 2; and XY represents a fragmentable electron donor moiety wherein: 1) XY has a an oxidation potential between 0 and about 1.4 V; 2) X is an electron donor group; 3) Y is a leaving group other than hydrogen; and 4) the oxidized form of XY undergoes a bond cleavage reaction to give the radical X• and the leaving fragment Y. In a preferred embodiment the radical X• has an oxidation potential of ≤ -0.7 V.

  感光元件包括至少一个卤化银乳剂层，其中的卤化银是用式 1 的化合物感光的。 Z-(L-XY)k 其中 Z 是光吸收基团 L 是连接基团，含有至少一个 C、N、S 或 O 原子的连接基团；以及 k 是 1 或 2；以及 XY 代表可碎裂的电子供体分子，其中 1) XY 的氧化电位在 0 至约 1.4 V 之间； 2) X 是电子供体基团 3) Y 是氢以外的离去基团；以及 4) XY 的氧化形式发生键裂反应，生成自由基 X- 和离去片段 Y。 在一个优选的实施方案中，自由基 X- 的氧化电位≤ -0.7 V。
• Photobleachable composition, photographic element containing the composition and photobleach method
  申请人：EASTMAN KODAK COMPANY

  公开号：EP1134613A1

  公开（公告）日：2001-09-19

  A UV or visible-light sensitive photobleachable dye composition substantially free of polymerisable monomer comprising a photobleachable dye and an N-oxyazinium compound, a photographic element containing such a photobleachable composition, and a method for bleaching a photographic element.

  一种基本上不含可聚合单体的紫外线或可见光敏感光漂白染料组合物，该组合物包含一种光漂白染料和一种 N-氧嗪化合物；一种含有这种光漂白组合物的感光元件；以及一种对感光元件进行漂白的方法。
• Sensitizing dyes for photographic materials
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0467370B1

  公开（公告）日：1998-05-13